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Method and kit for estimating side effect by paclitaxel therapy

A kit and paclitaxel technology, applied in biochemical equipment and methods, microbial measurement/testing, sugar derivatives, etc., can solve problems such as low allele frequency

Inactive Publication Date: 2011-04-06
JAPANESE FOUND FOR CANCER RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the allelic frequency of the genetic variation accompanying the amino acid variation disclosed in this application is all low

Method used

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  • Method and kit for estimating side effect by paclitaxel therapy
  • Method and kit for estimating side effect by paclitaxel therapy
  • Method and kit for estimating side effect by paclitaxel therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0108] The present invention will be described in more detail below using examples, but the examples are not intended to limit the scope of the present invention.

[0109] clinical samples

[0110] Fifty-four breast cancer patients were enrolled in a clinical trial of paclitaxel preoperative chemotherapy. The selection criteria for patients are 1) breast cancer patients who are 70 years old or younger and histopathologically confirmed as stage II or IIIa, 2) physiologically suitable (WBC>4000mm 3 , platelet count > 10000mm 3 , hemoglobin level>10g / dl, serum creatinine concentration2 Paclitaxel, instilled for 1 hour. Continuous administration for 12 weeks. The most frequent side effect observed in the above patients was neutropenia, identified in 24 patients.

[0111] Definition of side effects

[0112]In order to confirm the presence or absence of side effects, the number of white blood cells, red blood cells, hemoglobin, and platelets was measured weekly for each pat...

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Abstract

It is intended to disclose a method for risk estimation of the onset of granulocytopenia in a subject caused by paclitaxel treatment. This method comprises identifying gene polymorphisms in genes isolated from the subject, i.e., at five SNPs (IMS-JST111898 (SEQ ID NO:1), IMS-JST105874 (SEQ ID NO:2), IMS-JST082397 (SEQ ID NO:3), IMS-JST071852 (SEQ ID NO:4) and IMS-JST071853 (SEQ ID NO:5)) in CYP2C8 gene, and at five SNPs (IMS-JST074538 (SEQ ID NO:6), IMS-JST079837 (SEQ ID NO:7), IMS-JST044164 (SEQ ID NO:8), IMS-JST063023 (SEQ ID NO:9) and IMS-JST042569 (SEQ ID NO:10)) in BUB1b gene. Also, a kit containing a reagent to be used in this method is disclosed.

Description

technical field [0001] The present invention relates to a method for predicting the risk of onset of neutropenia, one of the side effects of paclitaxel therapy, by identifying gene polymorphisms, and a diagnostic kit for carrying out the method. Background technique [0002] Paclitaxel, also known as taxol (registered trademark), is a diterpene derivative alkaloid. Paclitaxel is an anti-tumor drug that stabilizes microtubules by promoting tubulin polymerization, causing excessive formation of microtubules, and inhibiting cell division by hindering the function of the spindle (Manfredi, J.J. and Horwitz, S.B. Taxol: an antimitotic agent with a new mechanism of action.Pharmac.Ther., 25:83-125, 1984) are widely used in the treatment of various cancers such as breast cancer, ovarian cancer, gastric cancer and non-small cell lung cancer. Various clinical trials are currently being conducted on the optimal dosage and regimen of paclitaxel therapy. One of the major side effects o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/09C12Q1/68C07H21/00
CPCC12Q1/6883C12Q2600/156C12Q2600/106C12Q2600/172C12N15/09C12Q1/6827
Inventor 三木义男松浦正明矶村实宫田敏吉本贤隆野田哲生
Owner JAPANESE FOUND FOR CANCER RES
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