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Compound blood pressure reducing preparation

A preparation and compound technology, applied in the field of medication for hypertension, can solve the problems of increased dosage, easy occurrence of adverse reactions, etc., and achieve the effects of improving blood pressure lowering effect, facilitating hypertensive patients, and reducing morbidity and mortality.

Active Publication Date: 2006-11-22
REYOUNG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the existing domestic and foreign clinical trials and relevant research evidence, from the perspective of improving the antihypertensive effect, reducing complications, and improving the quality of life, how to maximize the curative effect of treating hypertension and reduce blood pressure to a greater extent, and achieve This point is often beyond the reach of single drug therapy, or adverse reactions are prone to occur when the dose is increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Compound antihypertensive capsule batching of the present invention consists of:

[0033] Metoprolol 25g

[0034] Captopril 50g

[0035] Hydrochlorothiazide 12.5g

[0036] Starch 80g

[0037] Lactose 50g

[0038] Hypromellose 20g

[0039] Magnesium Stearate 10g

[0040] Talc powder 10g

[0041] A total of 1000 capsules are made

[0042] The preparation method is as follows:

[0043] ①Raw material processing: Weigh the raw materials of metoprolol, captopril and hydrochlorothiazide, mix them evenly, pulverize them, pass through a 100-mesh sieve, put them in the container for later use.

[0044] ② Processing of auxiliary materials: pass starch and talcum powder through a 160-mesh sieve, and magnesium stearate through a 80-mesh sieve, and set aside.

[0045] ③ Weighing: Weigh the starch, lactose, and hydroxypropyl cellulose according to the prescription amount, and plac...

Embodiment 2

[0054] Compound antihypertensive tablet batching of the present invention consists of:

[0055] Metoprolol 25g

[0056]Captopril 50g

[0057] Hydrochlorothiazide 12.5g

[0058] Microcrystalline Cellulose 40g

[0059] Lactose 50g

[0060] Hypromellose 20g

[0061] Magnesium Stearate 1g

[0062] A total of 1000 pieces were made

[0063] The preparation method is as follows:

[0064] ①Auxiliary material processing: pass the magnesium stearate through an 80-mesh sieve, and set aside.

[0065] ②Raw material processing: Weigh the raw materials of metoprolol, captopril, hydrochlorothiazide and microcrystalline cellulose, lactose, and hyprolose according to the prescription, mix them evenly, pulverize them, pass through a 100-mesh sieve, and place them in a container for later use .

[0066] ③Preparation of granules: Put the above-mentioned raw and auxiliary materials in a mixer, add appropriate amount ...

Embodiment 3

[0074] Compound antihypertensive sustained-release tablet of the present invention consists of ingredients:

[0075] Metoprolol 50g

[0076] Captopril 100g

[0077] Hydrochlorothiazide 25g

[0078] Starch 80g

[0079] Lactose 80g

[0080] Hypromellose 20g

[0081] Ethyl cellulose 10g

[0082] Magnesium Stearate 1g

[0083] A total of 1000 pieces were made

[0084] The preparation method is as follows:

[0085] ①Auxiliary material processing: pass the starch through a 160-mesh sieve, and pass the magnesium stearate through a 80-mesh sieve, and set aside.

[0086] ②Raw material processing: Weigh the raw materials of metoprolol, captopril and hydrochlorothiazide, starch and lactose according to the prescription, mix them evenly, pulverize them, pass through a 100-mesh sieve, put them in a container, and set aside.

[0087] ③ Weigh the prescribed amount of ethyl cellulose and hypromellose, swell with 80% et...

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Abstract

The present invention relates to one kind of compound hypotensor preparation, and belongs to the field of hypertension treating medicines. The compound hypotensor preparation contains the active components comprising metoprolol 25-100 weight portions, captopril 25-100 weight portions and hydrochlorothiazide 12.5-25 weight portions. The compound hypotensor preparation has high curative effect, less side effect high performance / cost ratio, taking convenience and raised patient's compliance. It is used mainly in treating hypertension, and may be also used in treating angina pectoris, heart failure and diabetes.

Description

technical field [0001] The invention relates to a compound antihypertensive preparation, which belongs to medicine for hypertension. Background technique [0002] Hypertension is a disease that seriously endangers human health and affects the quality of life. According to the latest data from the Center for Disease Control and Prevention of the Ministry of Health, there are more than 100 million hypertensive patients in my country, and the number is increasing at a rate of 3 million per year. Now there is one hypertensive patient in every 3 families on average, and 70% of hypertensive patients develop late stage Patients lead to cerebral apoplexy, 20% of hypertensive heart disease patients are combined with coronary heart disease, and 10% develop kidney disease. These are the main causes of death and major disability for Chinese residents. Every year, more than 1.5 million stroke patients are caused by high blood pressure. The rate ranks second in the world. In addition, 80%...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K31/138A61K31/401A61P9/12
Inventor 赵玉山胡凯
Owner REYOUNG PHARMA
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