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Medicine composition for treating hypertension complicated with hyperlipemia and cardiac and cerebral vascular diseases

A technology for cardiovascular and cerebrovascular diseases and hyperlipidemia, which is applied in the field of medicine

Inactive Publication Date: 2006-11-08
CSPC OUYI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patents disclose the pharmaceutical composition of the calcium ion antagonist amlodipine and the HMG-CoA reductase inhibitor, and their use in the treatment of atherosclerosis, angina pectoris, hypertension combined with hyperlipidemia, and the prevention of heart disease, etc. , but no reference to levamlodipine and therapeutic compositions containing levamlodipine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] The present invention will be described in further detail below in conjunction with examples.

[0044] Component

Example 1

2

3

4

5

L-Amlodipine Maleate

L-Amlodipine Besylate

Atorvastatin calcium

Simvastatin

β-cyclodextrin

Water

Microcrystalline cellulose

Compressible starch

Magnesium stearate

2.5

10

20

40

40

40

1

5

10

40

80

25

40

1

5

20

40

80

20

30

1

10

5

30

60

20

40

1

2.5

80

50

100

10

20

1

[0045] The above formula is the content of 1000 tablets, and the unit is gram.

[0046] Preparation method: Grind L-Amlodipine salt, β-cyclodextrin and water quickly and efficiently for 1 hour, then dry at 40°C under vacuum, pulverize, pass through a 100 mesh sieve, add the remaining materials, mix with a mixer for 10 minutes, and p...

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PUM

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Abstract

The medicine composition for treating hypertension complicated with hyperlipemia and cardiac and cerebral vascular diseases belongs to the field of medicine technology, and aims at raising the comprehensive curative effect. Technologically, the medicine composition consists of levoamlodipine and its medicinal salt, HMG-COA reductase inhibitor and its medicinal salt and medicine carrier, with the content being levoamlodipine 1.25-20 mg and HMG-COA reductase inhibitor 2.5-100 mg. Owing to the adding or synergistic effect of the medicines, the present invention has obviously raised medicinal effect, reduced dosage and obviously lowered side effect.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating hypertension combined with hyperlipidemia and cardiovascular and cerebrovascular diseases, and belongs to the technical field of medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases have always been the number one killer threatening human health. According to relevant survey reports, more than 3 million people die from cardiovascular and cerebrovascular diseases in my country each year, accounting for 50% of my country’s total deaths each year, and the disease is still getting worse. Declining age. Therefore, the research and development of drugs to treat cardiovascular and cerebrovascular diseases is one of the hot spots in the field of pharmaceutical research. [0003] Hypertension and hyperlipidemia are not only risk factors for cardiovascular and cerebrovascular diseases, but also are closely related to each other. Many hypertensive patients are accompanied...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/4422A61P3/06A61P9/12
Inventor 郭卫芹张育智彩辉
Owner CSPC OUYI PHARM CO LTD
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