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Medicine dragee suitable for children to take and its preparing method

A technology for children to take, medicine, applied in the field of medicine

Inactive Publication Date: 2006-11-08
毛晓敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention simultaneously provides a new preparation method for drug-containing sugar pills, so as to overcome the deficiencies of the current existing sugar pill preparation methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1 Amoxicillin sugar pill

[0056] 1. Formulation

[0057] Amoxicillin 125g

[0058] 200g powdered sugar

[0059] Compressible starch 70g

[0060] Mannitol 75g

[0061] Citric acid 3g

[0062] Vanillin 2g

[0063] Chlorophyll 1g

[0064] Magnesium stearate 0.5g

[0065] 2. Preparation method

[0066] Mix amoxicillin, sugar powder, compressible starch, mannitol, citric acid, and chlorophyll, granulate with 5% PVP ethanol solution, dry, add vanillin, magnesium stearate, and mix evenly. Compressed into sugar pills, coated.

[0067] Amoxicillin and the above-mentioned auxiliary materials are all passed through a 120 mesh sieve. When mixing, the materials are basically mixed by equal increment method, and then put into a ball mill to fully mix. 50% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

Embodiment 2

[0068] Embodiment 2 Amoxicillin / potassium clavulanate sugar pill

[0069] 1. Formulation

[0070] Amoxicillin 125g

[0071] Potassium clavulanate 31.25g

[0072] 150g powdered sugar

[0073] Pregelatinized starch 50g

[0074] Aspartame 1g

[0075] Micronized silica gel 1g

[0076] Magnesium Stearate 1g

[0077] Orange flavor 2g

[0078] 2. Preparation method

[0079] Mix amoxicillin, potassium clavulanate, sugar powder, pregelatinized starch, and aspartame, granulate with 4% PVP ethanol solution, dry, add orange flavor, micronized silica gel, magnesium stearate, and mix well , compressed into sugar pills.

[0080] Amoxicillin, potassium clavulanate and the above-mentioned auxiliary materials all pass through a 120-mesh sieve. When mixing, the materials are basically mixed by equal increment method, and then put into a ball mill to fully mix. 80% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity ...

Embodiment 3

[0081] Embodiment 3 Zinc gluconate sugar pill

[0082] 1. Formulation

[0083] Zinc Gluconate 35g

[0084] Powdered sugar 100g

[0085] Lactose 250g

[0086] Aspartame 1g

[0087] Micronized silica gel 1g

[0088] Magnesium Stearate 1g

[0089] Strawberry essence (powder) 2g

[0090] Monascus Pigment 3g

[0091] 2. Preparation method

[0092]The zinc gluconate is mixed with the above-mentioned auxiliary materials, and directly compressed into sugar pills.

[0093] Zinc gluconate and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. When mixing, the materials are basically mixed by equal increment method, and then put into a ball mill to fully mix. The content uniformity of the prepared sugar pills was determined to be good.

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Abstract

The present invention relates to medicine dragee suitable for children to take and its preparation process, and aims at providing new medicine preparation forms.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a medicine-containing sugar pill suitable for children and a preparation method thereof. Background technique [0002] Children's aversion to drugs is difficult to cooperate with clinical medication. Appropriate flavoring agents and coloring agents can cover up and correct the bad taste of drugs and beautify the appearance of drugs to a certain extent, so that patients, especially children, are willing to take them. This is very meaningful to alleviate the suffering of patients and ensure the normal progress of treatment. Sugar pill is a dosage form that is very popular among patients (especially children), and has many advantages: [0003] 1. Most of the medicines are bitter, and it is the nature of children to like sweetness. The sugar pill tastes sweet and is shaped like candy, which fully considers the characteristics of children's medicines. Children are easy to accept, have no psyc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K45/00
Inventor 毛晓敏
Owner 毛晓敏
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