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Celosia argentea suponin compound and its pharmaceutical use

A kind of technology of ginseng saponins and compounds, applied in the field of natural medicinal chemistry and medicine

Inactive Publication Date: 2006-10-25
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, up to now, there is no report in the literature that the saponins in Qinglong are used for the preparation of drugs for the prevention and treatment of liver disease, cardiovascular and cerebrovascular diseases, metabolic diseases, dementia, depression or anxiety.

Method used

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  • Celosia argentea suponin compound and its pharmaceutical use
  • Celosia argentea suponin compound and its pharmaceutical use
  • Celosia argentea suponin compound and its pharmaceutical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1. Qingruoside A is extracted

[0044] The present inventor utilizes the dried and mature seeds (the medicinal material is called Qinglizi) collected in Haozhou, Anhui, and extracts by percolation with aqueous ethanol after pulverization, and the extract is concentrated under reduced pressure to obtain a concentrated solution, which is passed through a macroporous resin column, followed by Gradient elution with water, 30% ethanol, 60% ethanol and 95% ethanol, the 30% and 60% ethanol eluents were respectively concentrated under reduced pressure and dried to obtain the total saponins (Qingyao extract) I and Qingyao respectively. The total saponins of Fructus L. (Qing Li extract) II, the total saponins of Fructus Fructus (Qing Lie extract) I and the total saponins of Fructus Fructus (Qing Lie extract) II are combined to obtain the total saponins of Fructus Fructus (Green Fructus extract). The total saponins of C. japonica were hydrolyzed and decolorized by acid ...

Embodiment 2

[0045] Embodiment 2. Qingruoside B is extracted

[0046] Heating and extracting Semen Chrysalis with water-containing ethanol, the extract is concentrated under reduced pressure to obtain a concentrated solution, the concentrated solution is passed through a macroporous resin column, and successively eluted with water, 30% ethanol, 60% ethanol and 95% ethanol gradient, and 60% ethanol The eluent was concentrated under reduced pressure and dried to obtain the total saponins of Fructus Lentigines (Fructus Lentigines extract) II. Carry out repeated silica gel column chromatography on the total saponins II of fennel, elute with chloroform-methanol (30:1~1:1) solvent system, collect the eluate of chloroform-methanol (2:1~1:1), and After the eluate was concentrated, it was applied to a silica gel column, eluted with a methanol-water (5:1-1:1) solvent system, and purified by reverse silica gel to obtain quincetin A and quincelein B in sequence.

Embodiment 3

[0047] Embodiment 3. pharmacological efficacy test

[0048] The method of above-mentioned each compound pharmacology and pharmacodynamics test is basically the same, below with the total saponins of Qingquan (Qingquan extract), Qingquglucoside A, Qingquanglucoside B as an example to describe in detail as follows:

[0049] 1. The prevention and treatment effect of saponins on liver diseases

[0050] In order to investigate the curative effect of Qinggui saponin in the treatment of acute and chronic liver diseases, Wood Invention has made in-depth pharmacodynamic experimental research, and the pharmacodynamic research has selected carbon tetrachloride (CCl 4 )-induced acute liver injury model in mice, chronic liver fibrosis model in rats and chronic fatty liver animal model induced by high-fat diet. The first two models are classic models for screening drugs for liver protection and prevention and treatment of liver fibrosis. The third model is recognized by everyone as having ...

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PUM

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Abstract

This invention relates to natual medicine chemical and medical technique field. It discloses two kind celosin new compounds of celosin A and celosin B structure and its distillation and eperating method from amaranthcea plant celosin. Their chemical general formula is shown as formula (1). This invention also discloses the compound and its derivative medicine aspect application of curing and preventing fatty liver, liver injury, hepatic fibrosis, liver cirrhosis, coronary heart disease, cardiac infarction, myocardial ischemia, cerebral ischemia, cerebral infarction, cerebral apoplexy, diabetes mellitus, hyperinsulinism, insulin resistance disease, obesity, glucose intolerance capability, and / or hypertension adiposity, hyperlipemia, dementia, depression or anxiety, and insomnia diseases.

Description

technical field [0001] The present invention relates to the field of natural medicine chemistry and medical technology, and relates to the structure of new celosia saponins extracted and separated from Celosia argentea L., and celosia argentea including the new compound and its derivatives Application in the preparation of medicines for treating and preventing liver diseases, cardiovascular and cerebrovascular diseases, metabolic diseases, dementia, depression or anxiety. Background technique [0002] Liver disease, cardiovascular and cerebrovascular diseases, metabolic diseases, dementia, depression or anxiety are all common and frequently-occurring diseases that endanger human health. Therefore, the research and development of effective drugs for the prevention and treatment of the above-mentioned diseases has always been the direction of efforts of scientific researchers. [0003] Semen Celosiae is the dry mature seed of Celosia argentea L. in the family Amaranthcea. Bi...

Claims

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Application Information

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IPC IPC(8): C07H15/256A61K31/56A61P1/16A61P3/10A61P9/10A61P25/22A61P25/24A61P25/28C07J61/00
Inventor 郭美丽薛芊张戈
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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