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Compound vitamin A acid gel preparation for treating acne and its preparing method

A technology of gel preparation and retinoic acid, which can be used in medical preparations containing active ingredients, pharmaceutical formulations, anhydride/acid/halide active ingredients, etc., and can solve the problem of weak apoptosis.

Inactive Publication Date: 2006-10-25
李海涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because MK plays a positive role in the growth and development of tumors, it is speculated that the apoptosis induced by ATRA alone is not very strong, but the combination with other inducers or cytokines such as cisplatin and interferon can enhance its effect. The reason may be related to the production of MK in the process of ATRA-induced apoptosis, but it remains to be confirmed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Raw material composition and weight proportion of embodiment 1 compound retinoic acid gel preparation

[0037] A compound retinoic acid gel preparation is characterized in that it is made of the bulk drug of the following weight ratio: per kilogram of gel dosage carbomer 20g, glycerin 80g, propylene glycol 260g, Tween 25g, triethanolamine 40g , clindamycin phosphate 20g (according to clindamycin), retinoic acid 0.3g, EDTA 2g, add distilled water to 1000g.

Embodiment 2

[0038] Embodiment 2 A kind of preparation method of compound retinoic acid gel preparation, its preparation steps are:

[0039] ①Add 20g of carbomer to about 50g of distilled water, add 80g of glycerin and 80g of propylene glycol, fully swell, add 40g of triethanolammonium and stir to form a transparent gel matrix;

[0040] ② Dissolve 20g of clindamycin phosphate in water, and dissolve 0.3g of retinoic acid with 100g of propylene glycol and 25g of Tween;

[0041] ③Add the above-mentioned liquid medicine into the transparent gel matrix in turn, add 2g of EDTA and 80g of propylene glycol;

[0042] ④ Make up distilled water to 1000g, stir to obtain light yellow transparent compound retinoic acid gel.

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PUM

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Abstract

The present invention discloses a compound gel preparation-compound tretinoin gel preparation for curing acnes. It is made up by using carbomer, glycerine, propylene alcohol, Tween, triethanolamine, clindamycin phosphate, tretinoin, EDTA and distilled water as raw material through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

Description

1. Technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a compound retinoic acid gel preparation for treating acne prepared by using Chinese medicinal materials as raw materials and a preparation method thereof. 2. Background technology [0002] According to related data reports, nearly 80% of people aged 12 to 25 suffer from acne. This potential huge market has attracted many pharmaceutical companies to develop acne medicines. Some people predict that blockbuster drugs may be produced in the field of acne drugs, so the market competition for acne drugs will become increasingly fierce. At present, foreign countries have begun to develop this new compound drug for the treatment of acne, but there is no such drug on the market in China. [0003] The compound compatibility technology of retinoic acid and clindamycin phosphate is adopted, and it is made into a gel dosage form. These are distinct from other acn...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/00A61K31/19A61P17/10
Inventor 李海涛
Owner 李海涛
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