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High density lipoprotein and its lipoprotein carrier used as anti coated virus medicine

A high-density lipoprotein and apolipoprotein technology, applied in antiviral agents, drug delivery, peptide/protein components, etc., can solve the problems of unseen HDL and its apolipoprotein literature reports

Inactive Publication Date: 2006-09-13
杨宝田
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no literature report on the use of HDL and its apolipoprotein in the treatment of diseases caused by enveloped viruses after searching

Method used

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  • High density lipoprotein and its lipoprotein carrier used as anti coated virus medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] HDL (with a purity of more than 95%) is extracted and prepared from human or animal plasma by ultracentrifugation, salting-out precipitation, organic solvent precipitation, polymer precipitation, column chromatography, etc. After virus inactivation, add an appropriate amount of Distilled water and NaCl, so that the concentration of NaCl is 0.85-0.90%, adjust the pH value to 7.0-7.6 with 1-5% NaOH solution, sterilize and filter, and pack under sterile conditions into each tube containing HDL 10mg, 25mg, The 50mg injection should be stored under proper conditions for future use. Other options should comply with the 2000 edition of the People's Republic of China under the injection.

Embodiment 2

[0108] HDL (purity above 95%) is extracted and prepared from human or animal plasma by ultracentrifugation, salting-out precipitation, organic solvent precipitation, polymer precipitation, column chromatography, etc., after virus inactivation, degreasing , make the apolipoprotein A (ApoA) that purity is more than 95%, add appropriate amount of distilled water and NaCl, make the concentration of NaCl be 0.85-0.90%, adjust pH value to 7.0-7.6 with 1-5% NaOH solution, remove Bacterial filtration, subpackage under aseptic conditions into injections each containing 10 mg, 25 mg, and 50 mg of HDL, and store under appropriate conditions for future use.

[0109] Other options should comply with the 2000 edition of the People's Republic of China under the injection.

Embodiment 3

[0111] Add appropriate amount of distilled water and NaCl to apolipoprotein A (ApoA) (purity above 99.8%) prepared by bioengineering technology, so that the concentration of NaCl is 0.85-0.90%, adjust the pH value to 7.0- 7.6, sterilize and filter, subpackage under aseptic conditions into injections containing 10ml, 25ml, and 50ml of HDL each, and store under appropriate conditions for future use. Other options should comply with the 2000 edition of the People's Republic of China under the injection.

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Abstract

An application of the high-density lipoprotein (HDL) and its apolipoprotein in preparing the liquid injection or freeze-dried powder injection for treating the envelope virus diseases including influenza, fowl influenza infection, SARS, AIDS, hepatitis B and C, etc is disclosed.

Description

Technical field: [0001] The invention relates to new medical applications of high-density lipoprotein and its apolipoprotein, and discloses the use of high-density lipoprotein and its apolipoprotein for preparing medicines for treating diseases caused by enveloped viruses. It belongs to the technical field of biopharmaceuticals. Background technique [0002] The high-density lipoprotein (abbreviation: HDL) involved in the present invention is a component in human and animal plasma, and the apolipoprotein of HDL includes ApoA, ApoC, ApoE, etc., mainly ApoA. HDL is negatively correlated with atherosclerosis and can be used to treat diseases caused by atherosclerosis. [0003] The medical field believes that enveloped viruses include: influenza virus (including avian influenza virus), SARS coronavirus, HIV, hepatitis B virus, rabies virus and other viruses with an envelope structure, which can cause human or animal influenza (including avian influenza virus) Influenza virus i...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K9/08A61P31/12A61P31/14A61P31/16A61P31/18A61P31/20A61P31/22
Inventor 杨宝田张兴义刘文芳徐举杨磊
Owner 杨宝田
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