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Quality control method of kidney beneficial bone fortifying capsule

A quality control method and bone-building technology, applied in capsule delivery, medical preparations containing active ingredients, bone diseases, etc., can solve problems such as incomplete drug quality standards, difficulty in controlling drug quality, and lack of content detection methods

Active Publication Date: 2006-08-30
JILIN AODONG YANBIAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the incomplete quality standards of the drug, it has brought difficulties to the production process and quality control. The existing technology lacks methodological research on determination, which has relatively large limitations; and due to the interference of other components, the reproducibility of the determination is poor.
Also lack the detection method of content in addition, especially as the capsule of solid preparation, its preparation quality can't be controlled more
[0004] For a long time, the quality of traditional Chinese medicine preparations has been difficult to effectively control. Effectively controlling the quality of traditional Chinese medicine products is a major issue. The methods used in the prior art are incomplete, and a few are not targeted. It is difficult to achieve the purpose of real quality control by using these methods
The above Yishen Jiangu Capsules are difficult to control the quality of the preparation due to the lack of good quality control methods; it has brought difficulties to normal production and operation, and it is difficult to provide a good quality control method for this preparation product by using known technologies. Aiming at the deficiencies of the existing technology, new methods are adopted to control the quality of Yishen Jiangu Capsules, especially the high-performance liquid chromatography is used to determine the content of active ingredients in the drug, which solves the problem of quality control of the preparation

Method used

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  • Quality control method of kidney beneficial bone fortifying capsule
  • Quality control method of kidney beneficial bone fortifying capsule
  • Quality control method of kidney beneficial bone fortifying capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] The preparation of embodiment 1 capsule

[0105] 【prescription】

[0106] Qiannianjian 180g Red Flower 60g Amomum Kernel 60g

[0107] Rehmannia glutinosa 180g Angelica 120g Polygonum multiflorum 180g

[0108] Salvia 120g Morinda officinalis 180g Eucommia 120g

[0109] Epimedium 240g Atractylodes macrocephala 120g Three seven 60g

[0110] Chuanxiong 120g Ginseng 60g Ligustrum lucidum 180g

[0111] Licorice 60g

[0112] [Preparation method] Ginseng is crushed into fine powder for the above sixteen medicinal materials; the other fifteen medicinal materials such as Polygonum multiflorum, add 8 times the amount of water and decoct three times, the first time for 3 hours, the second and third times for 2 hours each, and fry together liquid, filtered, and the filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.25 (measured at 80°C), mixed with the above-mentioned ginseng fine powder, dried, crushed into fine powder, added 3g of ma...

Embodiment 2

[0114] The quality control method of embodiment 1 capsule

[0115] 1), the character is observed, the method is as follows:

[0116] 【Properties】This product is a capsule, the content is brown to dark brown powder; slightly gas, bitter taste.

[0117] 2), identify the contents of angelica, chuanxiong, rehmannia glutinosa, salvia miltiorrhiza, licorice and ginseng, the method is as follows:

[0118] [Identification] 1. Take 4g of the content of this product, add 40ml of ether and 1ml of ammonia water, heat and reflux for 1 hour, take it out, let it cool, filter, evaporate the filtrate to nearly dry, add 0.5ml of ethyl acetate to dissolve the residue, and use it as a test product solution. Separately take 0.5 g each of Chinese angelica and Chuanxiong as reference medicinal materials, and make a solution of Chinese angelica and Chuanxiong as reference medicinal materials in the same way. According to the thin-layer chromatography ("Chinese Pharmacopoeia" 2005 edition one, appe...

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Abstract

A quality control method for the Chinese medicine in the form of capsule to nourish kidney and bone includes such steps as checking its characteristics, discrimination to Chinese angelica root, Chuan-xiong rhizome, fleece flower root, red sage root, liquorice root, ginseng and notoginseng, and measuring the content of icariin.

Description

technical field [0001] The invention relates to a quality control method of traditional Chinese medicine preparations, in particular to a quality control method of Chinese medicine Yishen Jiangu Capsules; Background technique [0002] Yishen Jiangu Capsule is a kind of medicine composed of Qiannianjian, safflower, amomum, rehmannia glutinosa, angelica, Polygonum multiflorum, Salvia miltiorrhiza, Morinda officinalis, Eucommia ulmoides, Epimedium, Atractylodes macrocephala, Panax notoginseng, Chuanxiong, ginseng, Ligustrum lucidum And licorice sixteen Chinese medicines to form a Chinese medicine compound preparation, its function and indications are Dai medicine: Tongsai Le Sailong, rare connection, oh long. Bing Mu Lanshen took Lu Duohuodan, and Bing Luen took the waist. Traditional Chinese Medicine: Replenishing liver and kidney, nourishing qi and nourishing blood, removing blood stasis and dredging collaterals. For chronic low back pain, limb pain, numbness, etc. caused b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/48A61P13/12A61P19/08G01N30/90G01N33/15
Inventor 关家华刘传贵王福文李振伟朱继忠李春燕董长萍张广民
Owner JILIN AODONG YANBIAN PHARM CO LTD
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