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Compound black-bone chicken soft capsule, its preparing method and quality control method

A technology of soft capsules and black-bone chicken, which is applied to the quality control of the preparation method of the preparation, and in the field of compound black-bone chicken soft capsules, which can solve the problems of discomfort for diabetics, inconvenience in carrying and transportation, and high sugar content

Inactive Publication Date: 2006-08-09
毛晓敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main problems in the prior art are: (1) the oral liquid is unstable, and it is easy to produce precipitation after long-term storage, and it is inconvenient to carry and transport; (2) the granule is inconvenient to take, and it needs to be taken after boiling water, and the amount of auxiliary materials is large; (3) the existing dosage form All exist sugar content height, be not suitable for the deficiency that diabetics take; (4) although existing dosage forms have added flavoring agents such as sugar, honey and carry out flavoring, mouthfeel is still not very satisfactory (5) the quality control of existing preparation lower standard
Due to its many advantages, soft capsules are a popular oral dosage form in the world, but there are still few traditional Chinese medicine soft capsules on the market, which are far from meeting people's medication needs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Embodiment 1: the extraction of yam, Radix Astragali, Radix Codonopsis, Poria cocos

[0091] Yam, Astragalus, Codonopsis, and Poria are extracted by water extraction and alcohol precipitation technology. While extracting active ingredients, it can effectively reduce the yield of ointment and reduce the introduction of ineffective ingredients such as starch.

[0092] The main factors affecting the effect of water extraction are the crushing degree of medicinal materials, the amount of water added, the decoction time, the number of decoctions and the soaking time. The soaking of medicinal materials before decoction has a certain influence on the decoction effect. The soaking time before decoction should be based on the soaking time of medicinal materials. Poria cocos and yam are not easy to soak in among these four herbs, so Poria cocos and yam fragments should be selected without hard core. After adding water, soak for 0.5, 1, and 2 hours to observe. Take out the poria c...

Embodiment 2

[0094] Embodiment 2: the extraction of black-bone chicken

[0095] Egg white can be hydrolyzed by acid to become peptides and amino acids that are more easily absorbed and utilized by the human body. The main factors affecting acid hydrolysis are acid type, acid concentration and dosage, concentration and time of heating hydrolysis. Taking the nitrogen content of black-bone chicken hydrolyzed powder as the investigation index, the useful amount of dilute sulfuric acid was determined. The experiments and results are shown in Table 2. It can be seen from Table 2 that the ratio of black-bone chicken weight to dilute sulfuric acid is 1:1.2 is better.

[0096] Test No.

Embodiment 3

[0097] Example 3: Extraction of other Qiwei medicines such as Rehmannia glutinosa

[0098] Rehmannia glutinosa, Atractylodes macrocephala, Radix Paeoniae Alba, Cortex Moutan, Rhizoma Chuanxiong, Angelica sinensis and Schisandra chinensis were infiltrated with ethanol at an appropriate concentration. The main factors affecting percolation were the crushing degree of the medicinal materials, the concentration and dosage of ethanol, and the rate of flow. According to experience, the flow rate can usually be fixed at 3-5ml / kg·min. The amount of percolation is collected with the end point of percolation until colorless. The key to percolation effect is the alcohol concentration. The concentration of ethanol is determined by the yield of extract and the amount of paeoniflorin, the active ingredient in Atractylodes macrocephala and Radix Paeoniae Alba. The tests and results are shown in Table 3. As can be seen from the results in Table 3, the ethanol concentration of 70% is better. ...

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PUM

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Abstract

The invention relates to a Chinese medicine-compound black-bone chicken soft capsule having functions of tonifying Qi and blood and benefiting liver and kidney and the preparing and quality control methods thereof. It has many advantages of stability, convenient to take and carry, no sugar, no bad smell, etc, and the quality control method comprises identifying White Paeony Root, cortex moutan radicis, Milkvetch Root, Radix Codonopsis, Chinese Angelica Root and Rhizoma Chuanxiong in the soft capsule, making content determination on the active substance of White Paeony Root and cortex moutan radicis-paeoniflorin in the soft capsule and controlling total nitrogen content of the soft capsule.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a compound black-bone chicken soft capsule, and at the same time relates to a preparation method of the preparation and a quality control method. Background technique [0002] Irregular menstruation due to qi and blood deficiency or liver and kidney deficiency, gynecological diseases such as spleen deficiency or kidney deficiency are common and frequently-occurring diseases in clinical practice. In traditional Chinese medicine, methods such as nourishing qi and blood and nourishing liver and kidney are often used for treatment. It is of great significance to carry forward the traditional advantages of traditional Chinese medicine and develop traditional Chinese medicine preparations that are stable, safe to use, accurate in dosage, controllable in quality, and reliable in efficacy. [0003] The prescription of "Compound Wuji Soft Capsule" is derived from the ministry ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K35/12A61K9/48A61P15/00G01N30/90G01N33/15A61K35/57
Inventor 毛晓敏
Owner 毛晓敏
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