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A quality detection method for a combination of medicines for treating cough, dyspnea and chest fullness

A quality inspection method and drug technology, applied in the field of pharmaceutical inventions, can solve problems such as decomposition of active ingredients, long heating and reflux time, blurred target spots, etc., and achieve the effects of reducing time cost, shortening drying time, and reducing heating time

Active Publication Date: 2021-02-02
贵州大隆药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the actual operation of this method, the test solution of the drug combination is prepared by this method and the heating and reflux time is long, which leads to the decomposition of the active ingredient, blurred target spots, and other problems, which affect the production of the drug combination. and quality inspection

Method used

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  • A quality detection method for a combination of medicines for treating cough, dyspnea and chest fullness
  • A quality detection method for a combination of medicines for treating cough, dyspnea and chest fullness
  • A quality detection method for a combination of medicines for treating cough, dyspnea and chest fullness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 【Properties】This product is granules, the content is light brown granules; sweet, slightly astringent.

[0031] [Identification] Take 4g of the drug, grind it finely, add 15-25ml of ethyl acetate-ethanol at a ratio of 4:1 to dissolve, heat and reflux in a water bath for 30min, filter, and evaporate the filtrate in a water bath to exhaust the air. Negative pressure environment, add 1ml of ethyl acetate to the residue to dissolve, filter, and the filtrate is used as the test solution;

[0032] Take 1.3g of cotton root reference medicinal material and 1.5g of pine cone reference medicinal material respectively, add 30ml of water to each, boil for 25 minutes, filter, and shake the filtrate with 10ml of ethyl acetate-ethanol solution with a ratio of 4:1. Dehydrate the water with sodium sulfate, filter, evaporate the filtrate to dryness, and the environment of evaporation to dryness is a negative pressure environment of exhaust air, add 0.5ml of ethyl acetate to the residue t...

Embodiment 2

[0046]【Properties】This product is granules, the content is light brown granules; sweet, slightly astringent.

[0047] [Identification] Take 5g of the drug, grind it finely, add 15ml of ethyl acetate-ethanol at a ratio of 4:1 to dissolve, heat and reflux in a water bath for 35min, filter, and evaporate the filtrate to dryness in a water bath. Pressure environment, add 1ml of ethyl acetate to the residue to dissolve, filter, and the filtrate is used as the test solution;

[0048] Take 1.4g of cotton root reference medicinal material and 1.5g of pine cone reference medicinal material respectively, add 35ml of water to each, boil for 25 minutes, filter, and shake the filtrate with 10ml of ethyl acetate-ethanol solution with a ratio of 4:1. Dehydrate the water with sodium sulfate, filter, evaporate the filtrate to dryness, and the environment of evaporation to dryness is a negative pressure environment of exhaust air, add 0.5ml of ethyl acetate to the residue to dissolve, filter, a...

Embodiment 3

[0062] 【Properties】This product is granules, the content is light brown granules; sweet, slightly astringent.

[0063] [Identification] Take 6g of the drug, grind it finely, add 25ml of ethyl acetate-ethanol at a ratio of 4:1 to dissolve, heat and reflux in a water bath for 40min, filter, and evaporate the filtrate to dryness in a water bath. Pressure environment, add 1ml of ethyl acetate to the residue to dissolve, filter, and the filtrate is used as the test solution;

[0064] Take 1.7g of cotton root reference medicinal material and 2.5g of pine cone reference medicinal material respectively, add 50ml of water to each, boil for 40 minutes, filter, and shake the filtrate with 10ml of ethyl acetate-ethanol solution with a ratio of 4:1. Dehydrate the water with sodium sulfate, filter, evaporate the filtrate to dryness, and the environment of evaporation to dryness is a negative pressure environment of exhaust air, add 0.5ml of ethyl acetate to the residue to dissolve, filter, ...

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Abstract

The invention relates to a quality detection method of a medicinal composition for treating cough, dyspnea and chest fullness. The composition consists of pine cones, cotton roots and loquat leaves. The quality detection method comprises: active ingredients pine cones, cotton roots, loquat Identification of leaves, determination of free gossypol residues in cotton roots. Free gossypol is a kind of polyphenolic hydroxyl bis-naphthaldehyde compound, which is a toxic substance that can cause redness, swelling and bleeding, nervous disorders, loss of appetite, weight loss, and affect fertility. On the basis of the original quality standard, the present invention optimizes the identification method, increases the identification of loquat leaves, and measures the residual amount of free gossypol in cotton roots, so that the quality monitoring level of the drug combination for treating cough, dyspnea and chest fullness has been significantly improved. Great improvement, the quality detection method has high accuracy and good stability, and can be effectively used for the quality detection of drug combinations for treating cough, asthma and chest fullness, and improves the quality standard.

Description

technical field [0001] The invention relates to the field of medical inventions, in particular to a quality detection method for a combination of medicines for treating cough, dyspnea and chest fullness. Background technique [0002] This product is composed of pine cones, cotton roots, and loquat leaves; among them: pine cones have the effects of eliminating phlegm, relieving cough, relieving asthma, chronic bronchitis, asthma, and coughing with excessive phlegm. Cotton root has the functions of relieving cough, eliminating phlegm and relieving asthma, but a toxic substance free gossypol may remain in cotton root. Free gossypol is a polyphenolic hydroxyl bis-naphthaldehyde compound, which can cause redness, swelling, bleeding, nervous disorders, Loss of appetite, weight loss, affect fertility. Loquat leaves have the effects of clearing the lung and relieving cough, harmonizing the stomach and diuresis, and quenching thirst. It has the effect of treating phlegm cough due t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90
CPCG01N30/90
Inventor 刘念宁徐卫东黄庚
Owner 贵州大隆药业有限责任公司
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