Policresulen foam aerosol and its prepn process

Abstract

The present invention discloses one kind of policresulen foam aerosol. The policresulen foam aerosol has softness, fineness, no excitation, excellent adsorption, excellent expansion and other advantages, can penetrate to mucous membrane goffer and other parts common medicine preparation can not reach to, and is suitable for use in body cavity. Clinic application shows that the policresulen foam aerosol is superior to corresponding spraying agent in treating cervicitis and vaginitis. The present invention also provides its preparation process.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a polycresol foam aerosol and a preparation process. Background technique [0002] Polycresol is a topical drug. Its main functions are: (1) It can selectively act on diseased epithelial cells and ectopic columnar epithelium, causing them to coagulate, degenerate, fall off, and promote tissue repair, but has no effect on normal squamous epithelial cells, No scars are left after the treatment of cervical erosion. (2) Promote the recovery of the vaginal physiological environment, which is conducive to the re-breeding of the natural flora. (3) It can shrink small blood vessels and stop bleeding quickly. (4) It can kill a variety of pathogenic microorganisms, such as bacteria, molds, trichomonas and certain viruses. Clinically used in (1) gynecology, increased vaginal and cervical secretions caused by bacteria, trichomonas, and candida, vaginitis, cervicitis; treatment of bleeding a...

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used dosage forms of polycresol sulfaldehyde in gynecology are suppositories, concentrates and sprays. Suppositories are solid preparations, which soften and dissolve slowly in the cavity, and the onset of action is slow, and the drug is not uniformly dispersed, and the local concentration is high. At the same time, it needs to be operated by hand when taking medication, which is unhygienic and easy to cross-contaminate. The patient has a foreign body sensation in the body, which brings discomfort to the patient.

The concentrated solution needs to be wiped with a cotton ball or diluted with water before being administered. The drug cannot fully contact the mucous membrane of the cavity, and the liquid is easy to flow in the cavity, which is also inconvenient to use.

Although the spray with water as the solvent can be directly sprayed on the local wound, the spray particle size of the spray is large, and it is not suitable to penetrate deep into the mucous membrane wall of the cavity, and the drug administration is uneven, which affects the circulation and brings inconvenience to the patient.

[0004] The lotion is used for external washing and internal spraying, but the contact time is short; external washing cannot penetrate deep into the lesion in the vagina, and the therapeutic effect cannot be achieved; internal spraying cannot fully affect the lesion, and the effect is not obvious

[0005] Suppositories have a long residence time (6-8 hours) and strong irritation when absorbing vaginal water, which creates hidden dangers for recurrence, and also produces discomfort such as dryness and foreign body sensation, which can easily destroy the acid-base balance

[0006] These dosage forms have a certain impact on the use of polycresol