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Preparation of vitamin E linolenin and vitamin E oleate

A technology of linolenic acid esters and vitamins, which is applied in the field of preparation of vitamin E linolenic acid esters and vitamin E oleic acid esters, can solve the problems of easy loss of activity, easy oxidative denaturation, etc., to enhance the original performance, reduce the level of oxidative denaturation, The effect of improving chemical stability

Inactive Publication Date: 2006-07-12
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that free vitamin E itself is easily oxidative and denatured during processing or storage, especially under the conditions of aerobic, metal ion or ultraviolet radiation, it is very easy to lose its activity.

Method used

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  • Preparation of vitamin E linolenin and vitamin E oleate
  • Preparation of vitamin E linolenin and vitamin E oleate
  • Preparation of vitamin E linolenin and vitamin E oleate

Examples

Experimental program
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Embodiment Construction

[0013] This embodiment takes the synthesis of vitamin E oleate as an example:

[0014] 1. Acid chloride synthesis method

[0015] 1.1 Synthesis of oleic acid chloride: 25g oleic acid (0.09mol) and 40ml anhydrous CHCl 3 Add it to a 100ml three-necked flask, cool it in an ice bath, and add distilled SOCl dropwise under stirring 2 20g (0.34mol), after 45 minutes of dripping, drop 1ml of pyridine, stir at room temperature for 2 hours, and then reflux for 4 hours until no gas is generated in the tail gas drying tube. First remove CHCl with water pump 3 and excess SOCl 2 , and then use an oil pump to distill under reduced pressure to collect 184-188□ / 6mmHg fractions to obtain a reddish-brown oily liquid. It has been identified that its refractive index is n D 20 =1.4620.(Document value: n D 20 = 1.4623).

[0016] 1.2 Synthesis of vitamin E oleate: add 0.984g (0.00228mol) of vitamin E, 1.4ml of dichloromethane and 0.07ml of pyridine into a 100ml three-necked flask, add 0.687...

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Abstract

The invention relates to a method for preparing for vitamin E leukotrienes ester and vitamin E oleate. It is characterized in that the oleic acid, linoleic acid or the leukotrienes dose esterification reaction and then reacts with the vitamin E Eoleate or vitamin E leukotrienes ester. The esterification reaction of the oleic acid, linoleic acid or the leukotrienes adopts chloride synthesis method, the anhydride synthesis method and the ester exchange synthesis method to prepare.

Description

technical field [0001] The invention relates to the preparation of vitamin E linolenate and vitamin E oleate. Background technique [0002] A large number of research results show that vitamin E has significant functions such as anti-oxidation, elimination of free radicals in the body, elimination of sexual disorders, promotion of blood circulation, prevention of premature aging, prevention of cancer, and improvement of body immunity. It is an extremely important drug and health nutrition product , is also a non-toxic and efficient natural antioxidant, widely used in medicine, food, cosmetics, feed and other fields. However, due to the fact that free vitamin E itself is easily oxidized and denatured during processing or storage, especially under the conditions of aerobic, metal ion or ultraviolet radiation, it is very easy to lose its activity. The experimental results show that vitamin E esterification modification can improve the stability of vitamin E. On the other hand...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/72
Inventor 李军生郑燕升粟晖许金蓉阎柳娟
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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