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Chinese medicinal extract, its preparation process and quality control method

A technology of extract and traditional Chinese medicine, applied in the field of extract and its preparation

Inactive Publication Date: 2006-07-12
代龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in fact, there is currently no method that can increase the total flavonoid content in the unique extract to more than 50% (that is, to reach the level of the "effective part" in new drug research).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] [Preparation method] Take 1000g of Duyiwei, crush it, add water to decoct three times, add water respectively 10, 8, and 8 times, each time for 1 hour, combine the decoction, filter (160 mesh sieve), and concentrate the filtrate to a relative density of about 1.30 (85 ℃) clear ointment, add ethanol to the clear ointment to make the alcohol content 50%, let it stand for 24 hours, take the supernatant, recycle the ethanol until there is no alcohol smell, pass the water through the macroporous resin column, and separate Elute with water, 20% ethanol, and 60% ethanol, collect the eluate of 60% ethanol, concentrate, dry (60°C, -0.08Mpa), and dry the paste into a fine powder. Add 60g of cross-linked polyvinylpyrrolidone, 40g of low-substituted hydroxypropyl cellulose, and 100g of microcrystalline cellulose, mix well, and granulate with 75% ethanol; add 40g of cross-linked polyvinylpyrrolidone, mix well, and dry (50° C. ), granulate, add micropowder silica gel 1g, and add appr...

Embodiment approach 2

[0035] [Preparation method] Take 1000g of Duyiwei, add 10 times the amount of water to decoct three times, each time for 1 hour, combine the decoction, filter (200 mesh sieve), and depressurize the filtrate (65°C-70°C, -0.08Mpa) Concentrate into a clear paste with a relative density of 1.12 (65°C), add ethanol to the clear paste to make the solution alcohol content 80%, let it stand for 12 hours, take the supernatant, recycle the ethanol until it has no alcohol smell, and recycle the ethanol The aqueous solution of the above polyamide column is passed through a polyamide column, and is eluted with water, 20% ethanol and 90% ethanol respectively, collects the eluate, concentrates, sprays dry, sprays dry powder and adds vegetable oil to adjust the total amount to 600g, colloid mill grinds for 20 minutes, and makes 1000 soft capsules, ready to use.

[0036] [Content Determination] Determination according to spectrophotometry (Appendix V B of Chinese Pharmacopoeia 2000 Edition). ...

Embodiment approach 3

[0042] [Preparation method] Take the unique medicinal material, crush it, decoct 3 times, add 8 times the amount of crude drug in water each time, decoct for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density at 85°C Clear ointment for 1.10-1.30.

[0043] Add an appropriate amount of ethanol to the clear paste to make the solution contain 70% alcohol, and recover the ethanol until it has no alcohol smell; put the above extract on the resin column, wash the column with water and 20% ethanol, and then wash with 50% ethanol Take off, collect eluate, dry,

[0044] Made into pellets, that is, too.

[0045] [Content Determination] Determination according to spectrophotometry (Appendix V B of Chinese Pharmacopoeia 2000 Edition).

[0046] a. Determination of total flavonoids by UV method

[0047] Preparation of Reference Substance Solution Accurately weigh 20 mg of rutin reference substance dried under reduced pressure at 120°C to co...

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PUM

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Abstract

The invention discloses a traditional Chinese medicinal Phlomis rotata Benth extract prepared through specific process, wherein the content of total flavones is above 50%. The invention also discloses the process for preparing the extract and the quality control method.

Description

technical field [0001] The invention relates to a medicinal extract derived from plant materials and a preparation method, in particular to an extract of unique medicinal material and a preparation method thereof, belonging to the field of traditional Chinese medicine. Background technique [0002] Duyiwei, Latin name Lamiophlomisrotata (Benth.) Kudo, belongs to Labiatae, Duyiwei genus, only 1 species, also known as Dubutong, also known as "Daba" and "Dabuba" in Tibetan. Its roots, rhizomes or whole plants are used as medicine. The surface of the medicinal material is yellow or yellowish-brown, hard, dry, and smelly. It is one of the commonly used herbal medicines in Tibetan, Mongolian, Naxi and other ethnic groups. It was first recorded in the famous Tibetan medical works "Four Medical Codes" and "Yuewang Medicine Diagnosis". The pharmacological research of the existing preparation Duyiwei Tablets, through hemostasis, analgesia, antibacterial, acute and subacute toxicity t...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/16A61K9/20A61K9/48A61K9/02A61P7/04A61P29/00G01N30/02G01N33/15A61K125/00
Inventor 代龙
Owner 代龙
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