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Method for separating Chinese medicinal active substances

A separation method and active ingredient technology, applied in the new separation field, can solve the problems of environmental pollution, high cost, and a large number of organic reagents, and achieve the effects of low operating costs, small footprint, and low investment

Active Publication Date: 2006-06-21
JIANGXI HUIREN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the products obtained by these methods have high purity, they all have the disadvantages of using a large amount of organic reagents, high cost, and polluting the environment.
Preliminary studies on the separation and enrichment of notoginseng saponins, ginsenosides and glycyrrhizin by foam separation have been reported, but the systematic research and reasonable evaluation system of this method as a separation and purification process of licorice water extract have not yet been reported.

Method used

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  • Method for separating Chinese medicinal active substances
  • Method for separating Chinese medicinal active substances
  • Method for separating Chinese medicinal active substances

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 as attached figure 1 . The production process flow of the invention is composed of an air compressor, a liquid conduit, a foam separation tower, a product storage tank and a blower. The foam separation tower is composed of a gas distributor, a bubbling section, a foam amplification section, and a foam outlet pipe. Each section is connected by a common ground joint, which can be installed freely, and the foam separation column can be flexibly added or subtracted, and it is beneficial to cleaning equipment. An air inlet pipe is connected under the gas distributor for inputting compressed air. The inner diameter of the foam outlet pipe is the same as the inner diameter of the separation column in the liquid phase section, and the angle is about 100 degrees. Among them, the foam breaking device: it is a fan, which can blow cold air to the foam, so that the foam can burst in time and become liquid. Its working process is:

[0050] Add 15 times the amount of w...

Embodiment 2

[0051] Example 2 as attached figure 2 . refer to figure 2 , The production process of the present invention is composed of raw material pool, preheating device, water pump, air compressor, gas rotameter, liquid rotameter, foam separation tower, foam breaking device, product storage tank, etc. The foam separation tower includes a gas distributor, a bubbling section, a foam amplification section, and a foam outlet pipe from bottom to top, and each section is connected by a common grinding port. An air inlet pipe is connected under the gas distributor for inputting compressed air. There is a discharge port on the right side of the housing above the gas distributor, and the outer end of the discharge port controls the liquid level. There is feed port A on the left side; there is feed port B on the left side of the shell above the separation column of the liquid phase section; there is feed port C on the left side of the shell above the separation column of the foam amplificat...

Embodiment 3

[0053] Example 3 as attached figure 2 . The production process flow chart of the present invention is the same as the continuous foam separation, the difference is that the operation steps are different. The graded foam separation is to first add 15 times the amount of water to the licorice decoction pieces (add 2 times more for the first time), decoct three times, each time for 2 hours, combine the filtrate, centrifuge, constant volume, refrigerate, and set aside. The pH of the medicinal solution is adjusted to alkaline, the pH is about 8, the air velocity is 600ml / min, the flow rate of the medicinal solution is 4L / h, the initial concentration of the medicinal solution is 0.81mg / ml (the concentration of glycyrrhizic acid), the temperature is room temperature, and the The liquid circulates and bubbles until the foam cannot accumulate, stop, and collect the foam product 1. Adjust the pH of the obtained residual liquid to about 4, and bubble again under the condition that the...

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Abstract

The invention relates to a method for separating active matter from traditional Chinese medicine, which in detail is to separate saponin and other surface active substance from traditional Chinese medicine coarse extraction solution; basing the difference of physicochemical property of the component in the traditional Chinese medicine water extraction solution, applying basal principle of foam phase separation, employing four different operation mode to separate and enrich the component from the liquorice coarse extraction, the technology is characterized by the no usage of chemical agent, low cost, simple device, simple device, small investment and no pollution to environment, the method is not only suited for liquorice coarse extraction, but also for other traditional Chinese medicine extracting solution containing saponin and other surface active substance, and is a feasible and effective new technology in the traditional Chinese medicine separating engineering.

Description

1. Technical field [0001] The invention relates to a new technology for extracting and separating traditional Chinese medicines, in particular to a new separation technology for separating and enriching surface active substances such as saponins from traditional Chinese medicines and their water extracts. 2. Background technology [0002] Saponins are a class of complex molecules that can produce a large amount of persistent foam when shaken in aqueous solution. They are composed of sugar chains connected with triterpenes, steroids or steroidal alkaloids through carbon bonds. They widely exist in the stems, leaves and roots of plants, such as ginseng, notoginseng, gynostemma, astragalus, licorice, holly, Polygala, Sapindus and so on. A large number of research results show that these saponins have a wide range of pharmacological effects and biological activities such as immunity, anti-tumor, anti-fungal, molluscicide, schistosomiasis, and cardiovascular disease prevention, e...

Claims

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Application Information

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IPC IPC(8): C07B63/00A61K36/00C07G3/00
Inventor 杨明苏艳桃韩丽马鸿雁王虎山兰洁李锐蔡培烈耿炤宋浩亮蔡金娜
Owner JIANGXI HUIREN PHARMA CO LTD
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