Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Vaginal effervesce tablet of ornidazole and its preparation method

A technology of ornidazole and effervescent tablets is applied in the field of ornidazole vaginal effervescent tablet formulation and preparation thereof, and can solve the problems of effervescent tablet expansion, rupture, and difficulty in controlling the amount of foaming.

Active Publication Date: 2006-05-03
NANJING SANHOME PHARMACEUTICAL CO LTD
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, it is not easy to control the amount of foaming through conventional preparation methods, and because of the addition of solubilizing ingredients, gas will be generated when it meets water, resulting in expansion, deformation, and rupture of effervescent tablets, so it is easy to deliquesce and deteriorate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The prescription consists of:

[0047] (a) Ornidazole 500mg / tablet

[0048] (b) Sodium bicarbonate 300mg / tablet

[0049] (c) Low-substituted hydroxypropyl cellulose 100mg / tablet

[0050] (d) Sodium lauryl sulfate 3.2mg / tablet

[0051] (e) Microcrystalline cellulose 440mg / tablet

[0052] (f) Tartaric acid 280mg / tablet

[0053] (g) polyethylene glycol 16mg / tablet

[0054] Taking the production of 100 ornidazole vaginal effervescent tablets as an example, the specific preparation method is to grind the raw and auxiliary materials in the prescription respectively through an 80-mesh sieve; weigh the prescription amount of ornidazole, sodium lauryl sulfate, bicarbonate Sodium, 75% of the prescription amount of microcrystalline cellulose, and 80% of the prescription amount of low-substituted hydroxypropyl cellulose are mixed evenly, and the soft material is made of 60% ethanol, granulated with a 14-mesh nylon sieve, and the wet granules are placed in an oven at 60°C Medi...

Embodiment 2

[0056] Check the stability of the product. Ornidazole vaginal effervescent tablets were prepared by the method described in Example 1 and placed to investigate the appearance and foaming amount of the product after 0 days, January, February, June, and December. The results are shown in the table below.

[0057] placement time

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an Ornidazole vaginal effervescent tablet, which comprises 1 weight part of Ornidazole, 0.54-0.66 weight part of sodium hydrogen carbonate, 0.18-0.22 weight part of low substituted methylcellulose propylene glycol ether, 0.0057-0.0070 weight part of sodium dodecylsulfate, 0.79-0.97 weight part of microcrystalline cellulose, organic acid 82% by molar weight of organic acid, 0.028-0.035 weight part of polyethylene glycol.

Description

technical field [0001] The invention relates to an ornidazole vaginal effervescent tablet preparation and a preparation method thereof. Background technique [0002] Ornidazole (CAS 16773-42-5), a nitroimidazole derivative, is a powerful drug against anaerobic bacteria and antiprotozoal infections. It is also a newly developed drug after metronidazole with higher efficacy and shorter treatment course , The third generation of nitroimidazole derivatives with better tolerance and wider distribution in the body. The antimicrobial effect of ornidazole is through the reduction of the nitro group in its molecule to an amino group in an oxygen-free environment, or through the formation of free radicals to interact with cell components, resulting in the death of microorganisms. Studies have found that ornidazole also plays an important role in the anti-broad-spectrum fungal infection (see esp.NO.CN1335132). In vivo and in vitro pharmacodynamic experiments, ornidazole is effective a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4164A61K9/20A61K9/46A61P15/02
Inventor 张仓腾再进
Owner NANJING SANHOME PHARMACEUTICAL CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com