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Formulations comprising an active ingredient and cocoa powder and use thereof

A technology for active pharmaceutical ingredients and preparations, applied in the field of preparations containing active ingredients and cocoa powder and their uses, capable of solving problems such as unsuitable for oral or oral preparations

Inactive Publication Date: 2006-04-26
麦克尼尔有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the lipid base Witepsol H-15 used is normally used in suppositories and is not suitable for oral or peroral formulations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Cocoa powder can be used in non-alkalized form and alkalinized form. Both can be used in the formulation of the present invention. When a slightly milder taste is required, alkalized cocoa powder is preferred.

[0039] Melt part of the hydrogenated soybean oil. Add solid components, that is, API (if solid) (Eritriptan hydrobromide is solid), cocoa powder, mannitol, corn starch, aspartame, acesulfame-K, titanium dioxide, chlorinated Sodium and flavoring agent (if solid), mix. Grind in a roller refiner to reduce the particle size of the solid components. If the solid components have reached the required particle size, for example, they are ground before mixing with the lipid components, roll refining is omitted. After processing in a roller refiner, the mixture is mixed with the remaining melted lipid components or re-melted (if cured) and mixed with the remaining melted hydrogenated soybean oil. The mixing of the melt is carried out in a suitable mixer. Add the liquid ...

Embodiment 2

[0040] Example 2: Preparation of another embodiment

[0041] Ingredients

Embodiment 3

[0042] Example 3: Preparation of another embodiment

[0043] Ingredients

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PUM

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Abstract

A pharmaceutical formulation suitable for oral ingestion comprising one or more active pharmaceutical ingredients (API) and cocoa powder, a process for the manufacture of the formulation, and the use of the formulation in medical procedures.

Description

Technical field [0001] The present invention relates to one or more active pharmaceutical ingredients (API), optionally containing its salts, complexes, prodrugs and metabolites, and further to a novel oral drug formulation containing cocoa powder; relates to one or The use of a variety of active pharmaceutical ingredients (API), optionally including their salts, prodrugs and metabolites, for the preparation of drugs that achieve pharmacological effects through oral administration; methods for medical treatment involving humans or animals, the method Including oral administration of one or more active pharmaceutical ingredients (API), optionally containing its salts, prodrugs and metabolites. [0002] Pharmaceutical formulations for oral administration of one or more active pharmaceutical ingredients (APIs) are required to provide rapid, preferably intraoral intake, such as sublingual and / or oral intake, and ingredients that adequately mask unpleasant tastes. Background technique...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/00A61K31/00A61K36/185A61K45/06
CPCA61K9/0056A61K9/006A61K9/2013A61K9/2068A61K36/185A61K45/06A61P1/04A61P1/08A61P3/10A61P9/06A61P9/08A61P9/12A61P11/06A61P11/08A61P21/02A61P25/04A61P25/20A61P25/22A61P29/00A61P43/00A61K2300/00
Inventor N-O·林德伯格K·E·A·林德尔A·C·马蒂诺F·P·尼科拉森K·M·蒂勒松
Owner 麦克尼尔有限公司
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