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Technique for preparing N-methylacetamide

A technology of methyl acetamide and methylamine, which is applied in the field of preparing N-methyl acetamide, can solve problems such as trouble, methylamine hydrochloride is highly corrosive, and is not suitable for industrialized large-scale production, and achieves environmental protection and solves the problem of Effects of Corrosion Problems

Inactive Publication Date: 2006-04-19
山东新华万博化工有限公司
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

The acetamide method reported in the early stage is troublesome to prepare acetamide, and methylamine hydrochloride is extremely corrosive when it evaporates, so it is not suitable for large-scale industrial production; while the organic acid and amine method provided by the later review, there is no Reports with process conditions

Method used

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Embodiment Construction

[0011] Add 200kg of acetic acid into the amination tank, then add 98kg of monomethylamine, and react for 2 hours at a reaction temperature of 70-80°C to generate crude N-methylacetamide, which is then transferred to a fractionation tank for finished products. In the fractionation of the finished product, first heat it under normal pressure to an air temperature of 99±2°C, and measure the acidity of the distillate with PH test paper, which means that the distilled water is over; ?35°C, take 100?10°C fraction, when the measured acidity is ≤1%g / ml, when the water content is ≤0.2%g / ml, the acid distillation is completed, and then transferred to the fractional distillation of the finished product. Under the condition of vacuum 0.096Mpa, the liquid The temperature is controlled at 125 to 35°C until it is evaporated to dryness, and 210kg of the finished product is obtained.

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Abstract

A process for preparing N-methylacetylamine from acetic acid and methylamine includes such steps as aminating, evaporating water, evaporating acid, and fractionating. Its advantage is no corrosion to apparatus.

Description

technical field [0001] The invention relates to a process for preparing N-methylacetamide with acetic acid and methylamine as raw materials. Background technique [0002] N-methylacetamide is an intermediate in organic synthesis of pesticides and medicines. Because it has good properties of dissolving organic matter, it is often used as a solvent in organic synthesis, such as widely used in the pharmaceutical industry as a solvent for the synthesis of cephalosporins. Regarding the preparation method of N-methylacetamide, there are few reports at home and abroad. The preparation method reported in the early stage is to complete the amino exchange reaction with acetamide and methylamine hydrochloride under co-melting, and the yield is 75%; However, most recent materials briefly introduce the preparation route of fatty acid amides in the form of a review, and use the corresponding organic acids and corresponding amines to obtain the desired amides through dehydration. The acet...

Claims

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Application Information

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IPC IPC(8): C07C233/05C07C231/02
Inventor 于祖荣王效梅刘昌娥徐芹
Owner 山东新华万博化工有限公司
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