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Chinese medicine effective part composition

A technology of effective parts and compositions, which is applied in the field of effective part compositions of traditional Chinese medicine, and can solve problems such as poor stability, imperfect extraction process, and low content of active ingredients

Inactive Publication Date: 2006-03-01
张文芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The extraction process prepared according to this method is not perfect, the content of active ingredients is low, and the stability is very poor. If no co-solvent is added, flocculent precipitation will appear after a period of time. The usual method is to add a certain amount of Tween-80
The adverse reactions in the clinical use of this injection are mainly because the unreasonable preparation process may increase the toxic components and reduce the content of active components in the Chinese patent medicine; the impurities in the preparation process are not completely removed, such as sugars, etc. can cause adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment one: preparation freeze-dried powder injection

[0022] Total ginseng saponins 1.5g Ophiopogon total saponins 5.0g Schisandra volatile oil 1g Schisandra total lignans 8g

[0023] Take an appropriate amount of cyclodextrin for injection (β or γ cyclodextrin), add it to 50ml of aqueous solution, fully dissolve, dissolve 1g of volatile oil of Schisandra chinensis and 8g of total lignans of Schisandra chinensis in an appropriate amount of ethanol solution, and slowly add the ethanol solution into the cyclodextrin In the dextrin solution, stir quickly until the solution is clear, and it is solution ①; take another 150ml of water for injection, add 1.5g of total ginsenosides, 5.0g of total saponins of Ophiopogon japonicus, and 3g of mannitol, fully dissolve into solution ②, and mix the solution ①② fully , add 0.1-0.5% activated carbon to remove the heat source, adjust the pH to 6.0-8.0, filter the mixture, put it in a vial, freeze-dry it, cap it, and pack it after ...

Embodiment 2

[0024] Embodiment two: preparation submicroemulsion injection

[0025] Total ginseng saponins 2.0g Ophiopogon total saponins 5.5g Schisandra volatile oil 1g Schisandra total lignans 5g

[0026] Schisandra volatile oil 1g, total lignans of Schisandra chinensis 5g, adding appropriate amount of cosolvent, heating and dissolving in 100g fatty acid triglyceride (wherein fatty acid carbon number is 5-24), 10g emulsifier (phospholipid 4g, F686g), 15g glycerin and appropriate amount of antibacterial The oxidizing agent is fully dispersed in water with a pH value of 10-12, mixed with oil and water, fixed to 500ml, stirred at a high speed at 50-80°C, homogenized by a high-pressure homogenizer, filtered and sterilized to obtain a solution ①;

[0027] Dissolve 2.0g of total ginsenosides and 5.5g of total saponins of Ophiopogon japonicus in 500ml of water for injection, add 4.5g of sodium chloride, remove the heat source with 0.1-0.5% activated carbon, adjust the pH to 6.0-8.0, sterilize a...

Embodiment 3

[0028] Embodiment three: preparation injection

[0029] Total ginseng saponins 2.0g Ophiopogon total saponins 5.5g Schisandra volatile oil 1g Schisandra total lignans 5g

[0030] Weigh 1g of volatile oil of Schisandra chinensis and 5g of total lignans of Schisandra chinensis, dissolve in an appropriate amount of ethanol, add appropriate amount of solutolHS15 or Tween 80 and a small amount of water, stir at 20°C-80°C to mix evenly, add water for injection to 100ml, and incubate at 20°C Stir at -80°C to make a microemulsion, remove the heat source with 0.1-0.5% activated carbon, adjust the pH to 6.0-8.0, sterilize and filter, filter and sterilize the solution, sterilize and filter, fill with nitrogen, and sterilize.

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PUM

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Abstract

The effective Chinese medicine part composition has the functions of benefiting vital energy, nourishing Yin, etc. The effective Chinese medicine part composition features that it includes total ginsenoside, total ophiopogonin, volatile schisandra oil and total schisandra lignin.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and specifically relates to a composition of effective parts of traditional Chinese medicines with the functions of nourishing qi, nourishing yin, and recovering veins. total lignans, Background technique [0002] The prescription and preparation method of Shengmai injection currently available on the market are as follows: [0003] [Prescription] Red Ginseng 100g Ophiopogon japonicus 312g Schisandra 156g [0004] [Preparation method] The above three flavors, crush the red ginseng into fine particles, extract with ethanol reflux 4-5 times, each time for 2 hours, use thin-layer chromatography to control the extraction end point, combine the extracts, refrigerate, filter, and concentrate the filtrate To a thick paste, add water for injection to 400ml, stir well, refrigerate, filter, and the filtrate is used for liquid preparation; 150ml of the distillate is collected from Schisandra chinensis by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8965A61K36/258A61P1/16
Inventor 张文芳
Owner 张文芳
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