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Medicinal composition containing red sage root extract and its application in preparation of medicine for preventing or treating cardiovascular and cerebrovascular disease

A composition and extract technology are applied to a pharmaceutical composition containing Salvia miltiorrhiza extract and its application field in the preparation of medicines for treating or preventing cardiovascular and cerebrovascular diseases, which can solve the problem of unstable curative effect, influence on compliance, and influence on treatment. effects, etc.

Inactive Publication Date: 2006-02-15
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the simple preparation process of Compound Danshen Tablets (coarse extraction of medicinal materials or grinding into powder for use as medicine), the active ingredients cannot be completely dissolved, and there is no effective quality control index, thus causing its curative effect to be unstable; The process has been improved, but the fat-soluble active ingredients of Salvia miltiorrhiza - tanshinones and water-soluble active ingredients - salvianolic acid are not controlled, which also affects its therapeutic effect, and because of its poor taste - bitter taste Astringent, causing its compliance to be affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0020] Preparation Example 1: Preparation of Salvia Miltiorrhiza Water-Soluble Components

[0021] Take the dried root of Salvia miltiorrhiza, crush it until it can pass through a No. 3 sieve, add 15 times of deionized water, stir at room temperature for 3 hours, and filter; add hydrochloric acid to the filtrate to adjust the pH to 2, let stand overnight, and filter; apply the filtrate to the processed The polyamide column, the ratio of loading sample amount (equivalent to crude drug amount) and polyamide consumption is 0.1: 1 (w / v), after washing 3 column volumes with water, wash 15 column volumes with 25% ethanol; Washing solution, washing solution and 25% ethanol eluate were all discarded. Finally, 6 column volumes were eluted with 60% ethanol, and this part of the eluate was collected, concentrated under reduced pressure at 60°C to an appropriate volume; freeze-dried to obtain salvianolic acid, and the measured salvianolic acid B content was 52%.

preparation Embodiment 2

[0022] Preparation Example 2: Preparation of Panax notoginseng glycosides

[0023] Take 1000g of Panax notoginseng coarse powder (20-40 mesh), add 10 times the amount of 70% ethanol to soak for 24 hours, continue to add 10 times the amount of 70% ethanol for percolation, control the flow rate of 3L / hour, collect the percolation liquid, recycle the ethanol, filter Pass through to obtain a clear aqueous solution, pass through an ADS-2 resin column, elute with 6 times the column volume of pure water, discard the water wash, continue to elute with 50% ethanol, collect the alcohol wash, concentrate, and dry to obtain off-white three Seven total saponins, its total saponin content is 60% after determination.

preparation Embodiment 3

[0024] Preparation Example 3: Preparation of Salvia Miltiorrhiza Fat-Soluble Components (Supercritical Extraction)

[0025] Take 500g of crushed Danshen medicinal material, put it into the extraction tank, open the device after sealing, adjust the extraction pressure to 20Mpa, the extraction temperature to 45°C, the separation temperature to 35°C, the CO2 flow rate to 20-25kg / h, the ethanol flow rate to 1L / h, and the extraction time to 2 hours, the salvia miltiorrhiza extract mainly containing fat-soluble components was obtained, and the content of tanshinone was determined to be 82%.

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PUM

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Abstract

The invention provides a medicinal composition of Danshen root extract containing liposoluble constituents and water-soluble constituents of Danshen, medicinal compositions containing Danshen extract and panax notoginseng saponins, and medicinal compositions containing Danshen extract, panax notoginseng saponins and borneo camphor. The invention also provides the use of the medicinal compositions in the preparation of medicaments for treating or preventing cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing salvia miltiorrhiza extract and its application in the preparation of medicines for treating or preventing cardiovascular and cerebrovascular diseases. Background technique [0002] Compound Danshen Tablets and Compound Danshen Dropping Pills are drugs recorded in the 2000 edition of the "Chinese Pharmacopoeia" [Pharmacopoeia of the People's Republic of China (Part One), 2000 Edition, 518-520]. Blood stasis, regulating qi and relieving pain are clinically used for the treatment of chest tightness and angina pectoris. Among them, compound Danshen dripping pills have the characteristics of high curative effect, rapid action and small side effects. It is generally believed that tanshinone IIA in Danshen and the main water-soluble active ingredient danshensu have pharmacological effects such as anti-myocardial ischemia and increasing coronary artery flow [Kong Xiangyun, chemical composition o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P9/10A61P9/00
Inventor 傅风华徐本明郑胜国田京伟
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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