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Asiabell polysaccharide tablet of asiabell effective ingredient

A technology of Codonopsis polysaccharides and active ingredients, which is applied in the field of Codonopsis polysaccharide tablets, which can solve the problems of not being able to meet the needs of clinical multi-dosage selection and market requirements, unable to guarantee the active ingredients of tablets, and large content of excipients. The effect of stable and controllable quality, small difference in tablet weight, and sufficient drug source

Inactive Publication Date: 2006-02-15
叶美曾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] A series of pharmaceutical dosage forms prepared from Codonopsis polysaccharide extracts include capsules, granules, oral liquids, and syrups. Although these dosage forms have their own advantages, they still cannot meet the needs of clinical multi-dose selection and market adaptation.
[0005] In addition, in the existing traditional Chinese herbal medicine tablet preparation process, the extract concentrate must be sprayed and dried, or the thick paste must be vacuum-dried or dried under normal pressure, and crushed into granules for tableting. If the thick paste is too viscous or too much, Thinner or fine powder of medicinal materials must be added, mixed evenly, dried, crushed into granules and pressed into tablets. Tablets produced by traditional techniques contain a large amount of excipients, which cannot guarantee the active ingredients in the tablets. Pharmacodynamic studies have shown that Codonopsis polysaccharides once The therapeutic dose is 1 to 1.5 grams. It is obviously not feasible to make the thick ointment into tablets by adding a diluent, and it may even cause adverse consequences.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1, taking the preparation of Codonopsis Codonopsis polysaccharide oral tablet as an example:

[0035] The tablet specification is 0.5g / tablet, and the preparation quantity is 300,000 tablets;

[0036] Weigh Codonopsis Codonopsis polysaccharide 300kg, low-substituted hydroxypropyl cellulose 3kg, magnesium stearate 1kg;

[0037] Preparation:

[0038] 1. Extraction method of Codonopsis Codonopsis polysaccharide, the active ingredient;

[0039] A. Dust removal and cleaning: the raw material Codonopsis pilosula removes impurities and mildewed drugs, and rinses with water;

[0040] B. Chopped: Cut Codonopsis pilosula into 2-4cm sections;

[0041] C. Decoction: Put the cut Codonopsis pilosula into a boiling pot for decoction, add 7-10 times of pure water, decoct 2-3 times, 2-3 hours each time, filter, and combine the filtrate;

[0042] D. Concentration: the combined filtrate is concentrated under reduced pressure to semi-fluid, with a specific gravity of 1.25-1.26,...

Embodiment 2

[0049] Example 2, taking the preparation of Codonopsis Codonopsis polysaccharide oral tablet as an example:

[0050] The tablet specification is 0.5g / tablet, and the preparation quantity is 500,000 tablets;

[0051] Weigh Codonopsis Codonopsis active ingredient Codonopsis polysaccharide 500kg, microcrystalline cellulose 3kg, magnesium stearate 1.5kg;

[0052] The preparation method is the same as in Example 1.

Embodiment 3

[0053] Example 3, taking the preparation of Codonopsis Codonopsis polysaccharide chewable tablets as an example:

[0054] The specification is 0.75g / piece, and the preparation quantity is 100,000 pieces;

[0055] Take Codonopsis polysaccharide 100kg, cocoa powder 25kg, sugar powder 20kg, magnesium stearate 0.5kg;

[0056] The preparation method is the same as in Example 1.

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PUM

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Abstract

Disclosed is an asiabell polysaccharide tablet of asiabell effective ingredient, wherein the main ingredients include codonopsis pilosula polysaccharides 100-600 parts, the auxiliary materials include low substituted methylcellulose propylene glycol ether or crystalline cellulose 2-4 parts, and magnesium stearate 0.5-1.5 parts, cocoa powder or mannitol.

Description

technical field [0001] The invention relates to a tablet prepared by using Codonopsis pilosula polysaccharide extracted from Codonopsis effective components. Background technique [0002] In the prior art, Codonopsis Codonopsis is the first choice in clinical practice of traditional Chinese medicine to invigorate the middle and replenish qi, invigorate the spleen and lungs, strengthen the body, strengthen the body and anti-aging, and is suitable for all syndromes of spleen and lung qi deficiency. Traditional Chinese medicine is composed of multiple components, and the physical and chemical properties and physical and chemical effects of its effective parts are very different. Through chemical research and pharmacological screening, it is confirmed that the active substance of the effective parts of Codonopsis Codonopsis is Codonopsis polysaccharides; The inventor of the paste has applied for a Chinese patent, the patent number is 200410012172.7; on the basis of the Codonopsi...

Claims

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Application Information

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IPC IPC(8): A61K36/344A61K31/715A61K9/20A61P1/14A61P39/06
Inventor 叶美曾郭小玲
Owner 叶美曾
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