Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dripping pills of tetrahydropalmatini sulfas and its preparation process

A technology of tetrahydropalmatine and sulfuric acid, which is applied in the direction of pharmaceutical formula, pill delivery, and medical preparations containing active ingredients, etc., which can solve the problem of large differences in pill weight, quality indicators, poor rounding rate of qualified products, and increased patient medication. Cost and other issues, to achieve the effect of small difference in pill weight, high rounding rate, and improved bioavailability

Inactive Publication Date: 2006-02-08
COSCI MED TECH CO LTD
View PDF1 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Application number is the Chinese patent of invention of 03157889.6, also discloses a kind of tetrahydropalmatine dripping pills in its open description, but the tetrahydropalmatine sulfate dripping pills prepared according to the preparation method disclosed in the above-mentioned prior art, In the test, the qualified product of its rounding rate is relatively poor, and the difference in pill weight is also quite different from the quality indicators of the relevant drop pill preparations stipulated in the national drug standards. Such products affect the dosage to a certain extent in use. The accuracy of the product also reduces the qualified rate of the product in production, increases the production cost, and indirectly increases the drug cost of the patient, thus reducing its practicability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dripping pills of tetrahydropalmatini sulfas and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] Now with several groups of specific examples, the preparation method of Tetrahydropalmatine Sulfate Dropping Pills of the present invention will be further described.

[0032] [Test prescription]

[0033] 1. Raw material - tetrahydropalmatine sulfate

[0034] 2. Base—a mixture of polyoxyl 40 stearate and polyethylene glycol, as follows:

[0035] 2.1 Polyoxyl 40 stearate: polyethylene glycol 2000 =1:1~1:10

[0036] 2.2 Polyoxyl 40 stearate: polyethylene glycol 4000 =1:1~1:10

[0037] 2.3 Polyoxyl 40 stearate: polyethylene glycol 6000 =1:1~1:10

[0038] 2.4 Polyoxyl 40 stearate: polyethylene glycol 10000 =1:1~1:10

[0039]2.5 Polyoxyl 40 stearate: polyethylene glycol 20000 =1:1~1:10

[0040] 3. The ratio of tetrahydropalmatine sulfate and matrix:

[0041] In g or kg, tetrahydropalmatine sulfate: substrate = 1:1~1:9

[0042] 4. Prepare according to the process of [Preparation Method] 4-7 ​​to obtain tetrahydropalmatine sulfate dripping pills of different specif...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Dripping pills of tetrahydropalmatini sulfas and its preparation process, wherein the pills are prepared from tetrahydropalmatini as raw material, and polyethylene glycol, polyoxyl (40) stearate as base material.

Description

technical field [0001] The invention relates to a pharmaceutical composition for analgesia, in particular to an oral preparation of a pharmaceutical composition prepared from tetrahydropalmatine sulfate as a raw material. Background technique [0002] Dl-tetrahydropalmatine (dl-THP) is an alkaloid extracted from the traditional Chinese medicine Corydalis Corydalis. -THP, also known as craniotidine). Both have been used clinically as analgesic and sedative drugs. The analgesic mechanism of Dl-THP is explained from traditional Chinese medicine as "activating blood and promoting Qi". According to current pharmacological studies, 1-THP is related to blocking central dopamine (DA) receptors. Its analgesic effect is weaker than pethidine, but stronger than general antipyretic analgesics, better for chronic persistent pain, less effective for trauma and postoperative pain. In addition to the analgesic effect, there are obvious sedative and hypnotic effects. The biggest advantag...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61K9/20A61P25/04
Inventor 王锦刚
Owner COSCI MED TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com