Compound injection formulation compose dof borneol and pseudo-ginseng total saponin and its preparing method

A technology of Panax notoginseng saponins and injection preparations, which is applied in the field of compound injections and its preparation, and can solve the problems of slow absorption of borneol, low content of borneol, and difficulty in reaching the effective concentration of drugs, etc.

Inactive Publication Date: 2005-12-21
JIANGSU CAREFREE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The distribution half-life of borneol for intravenous administration is 2.8 minutes, and it is quickly distributed to tissues and organs to exert curative effect, while the half-life of oral elimination is 5.3 hours, indicating that borneol is absorbed slowly and has low bioavailability
The content of borneol in a few injections such as Xinnaojing injection and Qingkailing injection is also very low, it is difficult to reach the effective concentration of the drug and affect the curative effect
[0007] The compound preparations of notoginseng and borneol are mostly oral preparations, such as compound salvia miltiorrhiza preparations, ice seven tablets, etc., because the oral preparations have a slow onset of action, especially in the acute attack period of cardiovascular and cerebrovascular diseases, they cannot take effect quickly and are difficult to achieve expectations The therapeutic effect of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of Bingqi Injection [1]

[0023] Take 20g of borneol (artificial or natural), grind it finely, add 1000ml of glycerin, heat and stir to dissolve completely. Get the raw material of Panax notoginseng total saponins (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 Total amount 50-90%) 200g add 2-4L water for injection to dissolve. Slowly add the glycerol solution of borneol into the aqueous solution of Panax notoginseng saponins, stir until clear while adding, and dilute to 10L with water for injection. The medicinal liquid is ultrafiltered through an ultrafiltration membrane with a pore size of 30,000 molecular weight, potted, 10 ml / bottle, and sterilized to obtain an injection.

Embodiment 2

[0024] Example 2 Preparation of Bingqi Injection [2]

[0025] Take 40g of borneol (artificial or natural), grind it finely, add appropriate amount of absolute ethanol to dissolve, then slowly add 600g of hydroxypropyl-β-cyclodextrin to a saturated aqueous solution, keep warm at 40-60°C, stir or sonicate Make the solution clear. Another raw material of Panax notoginseng total saponins (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 50-90% of the total amount) 200g, add appropriate amount of water for injection to dissolve. Slowly add the hydroxypropyl-β-cyclodextrin inclusion solution of borneol into the aqueous solution of Panax notoginseng saponins, stir, and add an isotonic osmotic pressure regulator to dissolve when making an infusion. The osmotic pressure regulator It is at least one of mannitol, sodium chloride or glucose, diluted to 20L with water for injection, and mixed well. The liquid medicine is ultrafiltered through an ultrafiltration membrane with a...

Embodiment 3

[0026] Example 3 Preparation of Bingqi infusion [1]

[0027] Take 10g of borneol (artificial or natural), grind it finely, add 2400ml of glycerin, heat and stir to dissolve completely. Get the raw material of Panax notoginseng total saponins (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 Total amount 50-90%) 200g add 2-4L water for injection to dissolve. Slowly add the glycerol solution of borneol into the aqueous solution of Panax notoginseng saponins, stir while adding, and add to an isotonic amount of osmotic pressure regulator, the isotonic agent is at least one of mannitol, sodium chloride or glucose, And dilute to 100L or 250L with water for injection, stir well. The medicinal solution is ultrafiltered by an ultrafiltration membrane with a pore size of 30,000 molecular weight, supplemented with an appropriate amount of water for injection, subpackaged into 100ml or 250ml / bottle, filled with caps, and sterilized to obtain an infusion solution.

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PUM

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Abstract

The present invention relates to a Chinese medicine compound injection preparation for curing angiocardiopathy and serebrovascular disease and its preparation method. Said compound preparation is made up by using Chinese medicinal material (synthetic or natural) borneol and notoginseng total saponin raw material (containing ginsenoside Rg1 and Rb1 and notoginsenoside R1 total content is 50-90%) according to weight mixing ratio of 1:5-20, and can be made into its compound injection (containing liquid injection, powder injection and infusion fluid). Said Chinese medicine compound injection preparation can be used for curing cerebral infarction, cerebral ischemia, coronary heart disease, angina pectoris and cardiac infraction, etc.

Description

[technical field] [0001] The present invention relates to a kind of Chinese medicine borneol (artificial or natural) and Panax notoginseng saponins raw material (containing ginsenoside Rg 1 , Rb 1 , notoginsenoside R 1 The compound injection (aqueous injection, powder injection and transfusion) composed of a certain proportion and a preparation method thereof. It belongs to the field of medical technology. [Background technique] [0002] Cardiovascular and cerebrovascular diseases are the number one killer that endangers human life and health. According to the latest statistics, 17 million people died of cardiovascular diseases in the world in 2000, accounting for 1 / 3 of the total number of deaths from various causes in the world. It is estimated that by 2020 This number will increase to 25 million in 2010, 80 percent of which will be in developing countries. [0003] According to the analysis of the causes of death in my country in 1997, among the causes of death among ...

Claims

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Application Information

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IPC IPC(8): A61K31/704
Inventor 秦引林彭国平何龙其
Owner JIANGSU CAREFREE PHARM CO LTD
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