Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gastric floating slow-release administrating system and its three-dimensional printing forming preparation method

A drug delivery system and gastric floating technology, applied in the field of medical drug preparation, can solve the problems of complex preparation process, many equipments, and difficulties in large-scale process, and achieve the effect of making up for prolongation, accelerating drug release, and compensating for the release route

Inactive Publication Date: 2005-12-21
HUAZHONG UNIV OF SCI & TECH +1
View PDF3 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the involvement of a variety of different materials and different processes, the preparation process is complicated and requires a lot of equipment. It is difficult to expand the scale process from laboratory research to industrial production.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gastric floating slow-release administrating system and its three-dimensional printing forming preparation method
  • Gastric floating slow-release administrating system and its three-dimensional printing forming preparation method
  • Gastric floating slow-release administrating system and its three-dimensional printing forming preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: Layer powder and binder deployment

[0033] Pass hydroxypropyl methylcellulose HPMC 4M, paracetamol, polyvinylpyrrolidone K30, and cetyl alcohol through a 200-mesh sieve respectively, and mix the powder with a particle size of less than 74 μm evenly to obtain a layered powder. Its raw material composition and content (weight parts) are as follows:

[0034] Acetaminophen 100 parts

[0035] Hydroxypropyl methylcellulose HPMC 4M 12 parts

[0036] Polyvinylpyrrolidone K30 9 parts

[0037] Cetyl alcohol 10 parts

[0038] Weigh 2 grams of ethyl cellulose (EC) powder at 5 cps, and dissolve 5 grams of polyvinylpyrrolidone K30 powder in 100 mL of 90% ethanol aqueous solution to prepare spraying adhesive 1.

[0039] Weigh 5 grams of polyvinylpyrrolidone K30 powder and dissolve it in 100 mL of 90% ethanol aqueous solution to prepare spraying adhesive 2.

Embodiment 2

[0040] Example 2: Determining 3D printing forming parameters

[0041] Layer spraying method:

[0042] 1~10 layers Spraying the entire garden surface of Φ10mm

[0043] 11-20 layers Spray a circle with a circumference of 2mm

[0044] 21~30 layers Spraying the entire garden surface of Φ10mm

[0045] Spray forming parameters:

[0046] Layer interval time 2min

[0047] Powder layer thickness 100~200μm

[0048] Spraying rate [spraying drop volume (droplet quantity × droplet size) × spraying frequency] 4nL × 12kz

[0049] Spraying times 2 to 3 times

Embodiment 3

[0050] Example 3: Preparation of gastric floating sustained-release drug delivery system containing ethyl cellulose

[0051] The operation of the 3D printing system is directly controlled by the computer terminal output command: first spread a layer of mixed powder with a thickness of 200μm, spray the binder 1 for 2 times, and after 2 minutes, the piston rod drives the powder bed of the workbench to descend as a whole, and then spread another layer The mixed powder with a thickness of 200 μm is sprayed and bonded to form, so that the three-dimensional printing forming parameters determined in Example 2 are repeated continuously to obtain a gastric floating sustained and controlled release drug delivery system. Then the obtained drug delivery system is dried and depowdered to obtain the finished product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The present invention discloses an endogastric flotation slow-released administration system, including medicine-loaded shell body and medicine-loaded kernel body, in which said kernel body is placed in the interior of said shell body, in the interior of said kernel body the air is held, and the specific weight of said endogastric flotation show-released medicine is less than 1g / cm. Said invention also provides the method for preparing endogastric flotation slow-released administration system by utilizing three-dimensional printing forming technique.

Description

technical field [0001] The invention belongs to the field of medical drug preparation, and in particular relates to a sustained and controlled release drug delivery system that can continuously float in gastric juice and release active ingredients in it at a relatively constant rate, and a preparation method for the system by three-dimensional printing. Background technique [0002] Gastric floating drug delivery system means that it is not affected by gastric emptying and can float on gastric juice for a long time, so that as much drug as possible can reach the absorption site in solution state and be absorbed, thereby improving drug bioavailability and prolonging drug action time a class of preparations. According to the floating mechanism, the ideal floating formulation has both good floating performance and improved drug release characteristics. However, the optimization of drug release and floating performance often affects each other, and it is difficult to coordinate...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00
Inventor 杨祥良余灯广刘卫徐辉碧孙望强
Owner HUAZHONG UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com