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Gout resisting Chinese medicine composition and its prepn process

A composition and an anti-gout technology are applied to an anti-gout traditional Chinese medicine composition. The preparation field of the traditional Chinese medicine composition can solve the problems of large dosage, poor bioavailability, etc. The effect of utilization

Inactive Publication Date: 2005-12-14
广州花海药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the majority of patients responded well to Tongfengshu Capsules, because the capsules are crushed medicinal materials and directly filled into capsules, the medicinal materials have not undergone any extraction process, and the bioavailability is poor. Make the best use of the formula

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of capsules of Chinese medicine composition of the present invention

[0021] a) Weigh 180g of rhubarb, 120g of plantain, 120g of Alisma orientalis, 120g of Achyranthes bidentata, and 60g of fangji according to the weight ratio;

[0022] b) Crush the tetrandrine into coarse powder, heat and reflux with 95% ethanol for two extractions, add 6 times the amount of ethanol for the first time, add 5 times the amount of ethanol for the second time, and extract for 1.5 hours each time with heating and reflux, then combine the two extracts , Filter, concentrate the filtrate under reduced pressure to an extract with a relative density of 1.20~1.30 / 60℃, dry it under vacuum to obtain dry extract 1, for use;

[0023] c) Extract the rhubarb with 70% ethanol under heating and reflux for two times, add 6 times the amount of ethanol for the first time, extract for 1.5 hours, and add 5 times the amount of ethanol for the second time, extract with heating and reflux for ...

Embodiment 2

[0027] Example 2 Preparation of tablets of the Chinese medicine composition of the present invention

[0028] It is basically the same as Example 1, except that f) the above-mentioned dry extract 1 and dry extract 4 are mixed, an appropriate amount of auxiliary materials are added, granules are made, and 1000 tablets are compressed.

[0029] The taking method and dosage of the above-mentioned capsules or tablets: Orally, 1-2 capsules (tablets) at a time, three times a day.

experiment example 1

[0030] Experimental example 1 Drug effect test

[0031] The traditional Chinese medicine composition of the present invention has obvious analgesic effects on mice pain caused by intraperitoneal injection of glacial acetic acid and heat stimulation. It has a significant inhibitory effect on acute inflammation models such as increased permeability of abdominal capillaries in mice caused by glacial acetic acid, swelling of rat carrageenan toes, and swelling of mouse ears caused by xylene. It also has a certain inhibitory effect on the subacute inflammation model of rat cotton ball granuloma. Using microcrystalline sodium urate-induced acute arthritis in rabbits, microcrystalline sodium urate-induced swelling of bare joints in rats, and hypoxanthine-induced hyperuricemia in mice, the anti-gout effect of the traditional Chinese medicine composition of the present invention was observed. It shows that the traditional Chinese medicine composition of the present invention can significant...

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PUM

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Abstract

The gout resisting Chinese medicine composition is prepared with alcohol extract of rhubarb in 90 weight portions and tetrandra root in 30 weight portions, water extract of plantain seed in 60 weight portions, oriental water plantain in 60 weight portions and achyranthes root in 60 weight portions, and supplementary material in proper amount. The preparation process includes the steps of: weighing material in certain proportion; preparing tetrandra root extractum through crushing, twice alcohol reflux extraction, etc; preparing rhubarb filtrate through alcohol reflux extraction, etc; preparing mixed filtrate of plantain seed, oriental water plantain and achyranthes root through twice decoctions, etc; mixing the rhubarb filtrate and the mixed filtrate, decompression concentration and drying to obtain mixed extractum; mixing tetrandra root extractum with the mixed extractum and supplementary material, pelletizing, tabletting and encapsulating.

Description

Technical field [0001] The present invention relates to an anti-gout medicine, in particular to an anti-gout Chinese medicine composition, and the invention also relates to a preparation method of the Chinese medicine composition. Background technique [0002] Uric acid deposits in connective tissue to form tophi, with an average appearance time of 10 years; after 10 to 20 years, many joints of the upper and lower limbs are involved, pseudo-rheumatoid arthritis may occur. Due to the frequent attacks of arthritis, the accumulation of urate in the joints increases, the swelling of the joints continues to disappear, the joints are deformed or stiff, and the joint activities are restricted. At the same time, tophi is formed in the bones of the joints, synovium, toughness, and under the skin of the earlobe. Direct touch through the skin can cause obvious tenderness, and white urate crystals are discharged after rupture. Some patients may also have comorbidities such as decreased renal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 吴智南黄能章招翠微周丽娟
Owner 广州花海药业股份有限公司
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