Medicinal composition for treating blood vessel kind disease, its preparation process and its use

A composition and drug technology, applied in the direction of drug combination, cardiovascular system diseases, pharmaceutical formulations, etc., can solve the problems not involved in Vinaorutong, etc., to achieve auxiliary improvement of brain insufficiency, improve energy metabolism in the brain, and promote brain function. The effect of internal protein synthesis

Active Publication Date: 2005-10-26
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] None of the above patents involves the combination of Vinaorutong and animal brain extracts to prepare new drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 10kg of fresh healthy pig brain, remove fascia and other impurities, wash with water for injection, add 10L water for injection, homogenate, adjust the pH value to 3.2, freeze and thaw once, heat to 80°C, keep for 20 minutes, and keep at 6°C Centrifuge at 4000 rpm for 20 minutes, filter the supernatant, adjust the filtrate to pH 7.0, heat to 80°C, keep for 20 minutes, and centrifuge at 2°C at 4000°C RPM, centrifugation time is 20 minutes, supernatant is filtered, filtrate is frozen at -18 ℃, thawed at 10 ℃, and then filtered, and the molecular weight cut-off of the filtrate is 10000 ultrafiltration membrane ultrafiltration (U.S. millipore company, standard ultrafiltration Filtration system), the ultrafiltrate is a brain extract, wherein the total nitrogen content is 3mg / ml, the polypeptide content is 11mg / ml, and the nucleic acid content is 7.5 / ml.

[0040] Weigh 80g of pure Vinaorutong for injection, mix it with 333ml brain extract to make 2000ml liquid medicine, ...

Embodiment 2

[0042] Take 10kg of fresh healthy pig brain, remove fascia and other impurities, wash with water for injection, add 10L water for injection, homogenate, adjust the pH value to 3.8, freeze and thaw twice, heat to 90°C, keep for 15 minutes, and keep at 4°C Centrifuge under the condition of 4000 rpm, the centrifugation time is 25 minutes, filter the supernatant, adjust the filtrate to pH 6.8, heat to 90 ° C, keep for 25 minutes, centrifuge at 4 ° C, the centrifugation condition is 4000 RPM, centrifugation time is 25 minutes, the supernatant is filtered, the filtrate is frozen below -20°C, thawed at 15°C, and then filtered, the filtrate is 8000 ultrafiltration membrane ultrafiltration with a molecular weight cut-off (U.S. millipore company, standard Ultrafiltration system), the ultrafiltrate is brain extract, wherein the total nitrogen content is 3.5mg / ml, the polypeptide content is 13mg / ml, and the nucleic acid content is 8.5 / ml.

[0043] Weigh 30g of pure Vinaorutong for injecti...

Embodiment 3

[0045] Take 10kg of fresh healthy bovine brain, remove fascia and other impurities, wash with water for injection, add 25L water for injection, homogenate, adjust the pH value to 3.3, freeze and thaw 3 times, heat to 85°C, keep for 15 minutes, and keep at 5°C Centrifuge at 4000 rpm for 30 minutes, filter the supernatant, adjust the filtrate to pH 7.2, heat to 85°C, keep for 15 minutes, and centrifuge at 6°C at 4000 RPM, centrifugation time is 30 minutes, the supernatant is filtered, the filtrate is frozen below -20°C, melted at 25°C, and then filtered, the filtrate is 10000 ultrafiltration membrane ultrafiltration with a molecular weight cut-off (U.S. millipore company, standard Ultrafiltration system), the ultrafiltrate is brain extract, wherein the total nitrogen content is 1.6mg / ml, and the polypeptide content is 11mg / ml.

[0046] Weigh 100g of pure Vinaorutong for injection, and mix it with 500ml of brain extract to make 2000ml of liquid medicine, and finally make 1000 sma...

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PUM

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Abstract

A medicinal composition for treating cerebrovascular diseases, craniocerebral trauma, cerebral disfunction, arteriosclerosis, thrombophlebitis, etc is prepared from 7,3',4'-trihydroxyethyl rutin and the liquid extract of the brain of mammal except man.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, its preparation method and its application, in particular to a pharmaceutical composition of brain extract extracted from the brain tissue of mammals other than humans and venaolutong, and its preparation The method and its use in the preparation of medicines for treating acute and chronic cerebrovascular diseases and the sequelae caused by them, such as brain dysfunction. Background technique [0002] Vinaolutong (also known as troxerutin) is a water-soluble flavonoid compound obtained by semi-synthesis of rutin through hydroxyethylation. D)-based mixture of hydroxyethyl rutin, generally used for medicine, calculated as anhydrous substance, containing troxerutin (C 33 h 42 o 19 ) shall not be less than 80.0% (for injection) and 60.0% (for oral use). Vinaorutong can inhibit the aggregation of platelets and has the effect of preventing thrombosis. At the same time, it can resist vascula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/30
Inventor 姜耀玲
Owner JILIN SIHUAN PHARM CO LTD
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