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Ao meilazole sodium injection liquid

A technology of omeprazole sodium and injection, which is applied in the field of omeprazole sodium injection and its preparation, and can solve problems such as instability of omeprazole

Inactive Publication Date: 2005-10-26
马志民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The injections currently used in the market are powder injections. Omeprazole needs to be dissolved in a special solvent due to its instability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1, the specification of commercially available omeprazole sodium powder for injection is 40mg / , and the clinical dosage is usually each 40mg, for the convenience of clinical medication, the specification of omeprazole sodium injection is designed as 40mg / support (calculated as omeprazole).

[0009] Ingredients: Omeprazole Sodium 42.7g±10%, EDTA Disodium 1g, Polyethylene Glycol-400 1000ml, filled with nitrogen gas to prepare 1000 vials of injection.

[0010] Preparation method: In the aseptic operation room, weigh omeprazole sodium and edetate disodium according to the prescribed amount, add the prescribed amount of polyethylene glycol-400, stir for 30 minutes to dissolve, and then add the prepared amount 0.02% activated carbon for injection, fully stirred, coarsely filtered, and then finely filtered with a 0.22 μm microporous membrane to measure the content of omeprazole sodium in the solution, determine the exact filling volume, sub-package, fill with nitrog...

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PUM

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Abstract

A liquid injection of omeprazole sodium is prepared from omeprazole sodium, Na2EDTA, and polyethanediol-400. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to an omeprazole sodium injection and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Omeprazole (Omeprazole) is a derivative of benzomidazole, the chemical name is (±)-5-methoxy-2 (4-methoxy-3,5-dimethyl-3-pyridyl)methylbenzimidazole has a strong and long-term inhibitory effect on gastric acid secretion in animals and humans, and is widely used at home and abroad Satisfactory results have been achieved in the treatment of peptic ulcer, reflux esophagitis, and gastrinoma. The earliest dosage form of omeprazole on the market was oral preparations, but due to the strong first-pass effect of oral preparations, powder injection and injection dosage forms were developed later. Intravenous injection, directly into the blood, rapid onset of action. Moreover, for patients with severe emergencies, coma, anesthetized patients and other patients who are inconven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439
Inventor 马志民
Owner 马志民
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