Method and use for constructing AIDS primate model

A technology of primates and construction methods, which is applied in the direction of pharmaceutical formulations and preparations for in vivo experiments, etc., and can solve the problems of unclear effects of animal infection models and no disclosure of construction methods

Inactive Publication Date: 2005-10-19
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology

[0006] Although it is known that many primate infection models for different pathogens have been established, in terms of establishing a primate infection model for AIDS, the selection of animal species, health status, treatment of infected viruses, dosage, route and There are a lot of technical problems in post-infection virus detection, immunoserological determination and other links that need to be solved urgently
Foreign literatures on HIV-infected primate infection models do not disclose the specific construction method, and the effect of the obtained animal infection model is not very clear

Method used

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Embodiment

[0032]1. Animal selection: Choose one adult macaque, one male and one male, and conduct re-examination according to the SPF level of the national standard microbes for experimental monkeys before inoculation, and check the HIV antibody. Serological tests for SIV, simian retrovirus type D (SRV) and simian T lymphocytic virus type I (STLV-I) antibodies were negative;

[0033] 2. Virus inoculation

[0034] The SIVmac 251 presented by Professor Marx of the Aarond Diamond AIDS Research Center in the United States was amplified in vitro by PBMC from healthy monkeys, infected monkeys intravenously, titrated the virus titer, and infected intravenously with a dose of 5MID 100. Use and Experimental Procedures" were carried out in the AIDS-specific animal laboratory of the Institute of Experimental Animals, Chinese Academy of Medical Sciences.

[0035] 3. Relevant performance of animals after vaccination

[0036] 3.1. Acute infection period: It is characterized by an acute increase in ...

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Abstract

The present invention discloses a kind of HIV infection model of Chinese macaque as one kind of primate animal. HIV is inoculated to Chinese macaque via intravenous injection to constitute the HIV infection model of Chinese macaque successively. By means of understanding the infecting course, pathological characteristic, pathogenesis and body's resistance of HIV inside the model, are researched the infected target organ, target tissue and target cell, the attack to the immunity system, the reaction of the immunity system cell, etc. The HIV infection model has non-replaceable effect in AIDS research, anti-AIDS medicine screening, vaccine evaluation, etc.

Description

technical field [0001] The invention relates to a primate model of AIDS, especially a construction method and application of a rhesus monkey acute and chronic AIDS infection model. Background technique [0002] Since the first report of AIDS cases in my country in 1985, the prevalence of AIDS has shown a rapid upward trend. In 2003, the Ministry of Health, together with relevant international organizations, conducted a nationwide AIDS epidemiological survey. The preliminary analysis showed that there were about 840,000 HIV-infected people in China, including about 80,000 AIDS patients. As of 2003, Beijing alone has accumulatively found 1,648 cases of HIV infection, ranking seventh in the country. Some experts warned that if AIDS is not curbed, by 2010, the number of people infected with AIDS in my country will surge to 10 million, and the number of such patients in Beijing will be close to 20,000. After 2010, the growth rate of AIDS will continue to radiate. sexual growth. ...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 卢耀增吴小闲秦川何伏秋涂新明张永荣魏强李国桥符林春郭卫中陈颂
Owner INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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