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Granules of clarityne and their production

A technology of loratadine and granules, which is applied in the field of loratadine granules and its preparation, can solve problems such as being difficult for children to accept, and achieve the effects of easy acceptance, sweet taste and good solubility

Inactive Publication Date: 2005-10-12
南京亿华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention just aims at the shortcoming that the existing dosage form is not easy to be accepted by children, and provides a kind of loratadine granule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1. Preparation of Loratadine Granules (wet method) First, the original and auxiliary materials are all placed in 60° C. and dried for 4 hours, and set aside; then, get 5 g of Loratadine and 5 g of citric acid, and Mix evenly by increasing the amount, pass through a 60-mesh sieve; add 15g of sodium carboxymethylcellulose, and then add 20% dilute ethanol solution to make soft materials, pass through a 20-mesh sieve to make wet granules, dry at 50°C-60°C for 3-4 Hours, through 18-mesh sieve for granulation, packaged in aluminum-plastic composite film, 1g per package, containing 5mg of loratadine.

Embodiment 2

[0028] Embodiment 2. The preparation of loratadine granule (wet method)

[0029] First, put the raw material and auxiliary materials at 60°C and dry for 4 hours, and set aside; then, take 5 g of loratadine, 1000 g of sucrose, 5 g of citric acid, and 5 g of strawberry essence and mix them evenly in equal increments, and pass through a 60-mesh sieve ; After adding 15g of sodium carboxymethyl cellulose, add 20% dilute ethanol solution to make soft materials in an appropriate amount, pass through a 20-mesh sieve to make wet granules, dry at 50°C-60°C for 3-4 hours, pass through a 18-mesh sieve for granulation, add Food coloring 1.5g, packed in aluminum-plastic composite film, 1g per pack, containing 5mg of loratadine.

Embodiment 3

[0030] Embodiment 3. The preparation of loratadine granule (dry method)

[0031] First, put the raw materials and auxiliary materials at 60°C to dry for 4 hours, and set aside; then, take 5 g of loratadine, 1000 g of glucose, 5 g of citric acid, and 5 g of strawberry essence, mix them evenly according to the method of equal increase, and pass through 60 mesh Sieve; pass through a 18-mesh sieve to granulate, and mix with 1.5g food coloring. Aluminum-plastic composite film packaging, 1g per package, containing 5mg of loratadine.

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PUM

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Abstract

A particle of loratadine is prepared proportionally from loratadine, citric acid, and the additive chosen from edible essence, sweetening agent and edible pigment.

Description

1. Technical field [0001] The invention relates to loratadine granules and a preparation method thereof 2. Background technology: [0002] Loratadine has quick onset and strong effects in clinical application, and is a new generation of selective peripheral H without sedative side effects on the central nervous system. 1 receptor antagonists. It can effectively relieve the symptoms and signs of allergic rhinitis, chronic urticaria, itchy skin diseases and other allergic skin diseases, and can also effectively relieve the symptoms of sneezing, runny nose, nasal itching and nasal congestion caused by cold or flu. [0003] Loratadine is widely used because of its good safety profile. Most of the dosage forms of loratadine on the market are tablets and syrups. The problem of taking the tablet and the mouthfeel problem of the syrup are common problems in the clinical application of loratadine to children. 3. Contents of the invention [0004] The present invention provides ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/445A61P11/02A61P17/04A61P37/08
Inventor 杨鹏辉
Owner 南京亿华药业有限公司
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