Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for clarifying liquor of Chinese traditional medicine by using membrane separation

A technology for membrane separation and clarification, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery. Improve the effect of physical and chemical stability

Inactive Publication Date: 2005-08-31
TIANJIN UNIV
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The obtained liquid medicine generally has the following problems: ① the appearance of the liquid medicine is relatively turbid, and there are a large amount of suspended matter; Precipitation appears at the bottom; ③ The impurity removal rate of the liquid medicine is low, and the dosage of the medicine is large
[0003] Existing methods for producing liquid medicine mainly include static method, alcohol extraction method, and coarse filtration method, and their production cycle is long, cost is high, and effect is poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1 The membrane method refining clarification of certain medicine liquid

[0011] Weigh Magnolia officinalis officinale, Schizonepeta fringe, Moutan Cortex in proportion to 500 grams altogether, reflux extraction at 95 ℃ twice, first time add 60% ethanol of 5 times of raw material medicine, add 60% ethanol of 3 times of raw material medicine for the second time , each time for 1.5 hours, the combined extracts were subjected to high-speed centrifugation at 5000r / min for 25min to remove the precipitate to obtain the ethanol extract. Weigh 1707.5 grams of concentrated powder of Bupleurum, Scutellaria, Anemarrhena, Artemisia annua, Betel nut, Rhubarb, and buffalo horn in proportion, add water to decoct twice, add 8 times the amount of water for the first time, and add raw materials for the second time 7 times the amount of water, each time for 2 hours, combined the decoction, concentrated to 3000 g, and removed the precipitate by high-speed centrifugation at 5000r...

Embodiment 2

[0014] Adopt the method of embodiment one to obtain mixed liquid A. The mixed solution A was recovered ethanol at a vacuum degree of 0.08MPa and a temperature of 50°C and concentrated to a certain amount, and the precipitate was removed by high-speed centrifugation at 5000r / min for 10 minutes to obtain the mixed solution B. The mixed solution B is cross-filtered at 0.06 MPa through a cellulose acetate membrane with a pore size of 0.22 μm-nitrocellulose microfiltration membrane, and the permeate is collected as the clarified solution of traditional Chinese medicine.

[0015] The clarity of the syrup prepared by the membrane separation method is about 85%-90% lower than that of the syrup produced by the original process, and the stability of the clarity for long-term storage is significantly improved.

Embodiment 3

[0017] Adopt the method of embodiment one to obtain mixed liquid A. The mixed solution A was recovered ethanol at a vacuum degree of 0.04MPa and a temperature of 45°C, concentrated to a certain amount, and the precipitate was removed by high-speed centrifugation at 5000r / min for 10 minutes to obtain the mixed solution B. The mixed liquid B is cross-flow filtered at 0.08 MPa through a cellulose acetate membrane with a pore size of 0.45 μm-nitrocellulose microfiltration membrane, and the permeated liquid is collected as the clarified liquid of traditional Chinese medicine.

[0018] The clarity of the syrup prepared by the membrane separation method is about 80%-85% lower than that of the syrup produced by the original process, and the stability of the clarity for long-term storage is significantly improved.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for clarifying the decoction or liquid extract of Chinese medicine by membrane separation includes removing impurities by centrifugal separation or filtering, recovering the extracting solvent by evaporating, centrifugal separation of deposit, and membrane filtering by the millipore acetate cellulose-nitrate cellulose.

Description

technical field [0001] The invention relates to a method for membrane separation and clarification of traditional Chinese medicine liquid, which belongs to the purification and clarification technology of traditional Chinese medicine liquid. Background technique [0002] The traditional production process of medicinal liquid mainly includes three parts: extraction, impurity removal and monosaccharide addition. The obtained liquid medicine generally has the following problems: ① the appearance of the liquid medicine is relatively turbid, and there are a large amount of suspended matter; Precipitation appears at the bottom; ③The impurity removal rate of the liquid medicine is low, and the dosage of the medicine is relatively large. [0003] Existing methods for producing medicinal liquid mainly include standing method, alcohol extraction method and coarse filtration method, which have long production cycle, high cost and poor effect. Compared with tr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08
Inventor 姜忠义吴洪王姣马小乐王艳强王婷
Owner TIANJIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com