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Method for clarifying liquor of Chinese traditional medicine by using membrane separation

A membrane separation and traditional Chinese medicine technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of sticking to the wall, poor effect, and large dosage of medicines, shortening the production cycle, and achieving physical and chemical stability. Good, clarity-improving effect

Inactive Publication Date: 2006-11-22
TIANJIN UNIV
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AI Technical Summary

Problems solved by technology

The obtained liquid medicine generally has the following problems: ① the appearance of the liquid medicine is relatively turbid, and there are a large amount of suspended matter; Precipitation appears at the bottom; ③ The impurity removal rate of the liquid medicine is low, and the dosage of the medicine is large
[0003] Existing methods for producing liquid medicine mainly include static method, alcohol extraction method, and coarse filtration method, and their production cycle is long, cost is high, and effect is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The membrane method refining clarification of embodiment one certain medicine liquid

[0011] Weigh Magnolia officinalis officinale, Schizonepeta fringe, Moutan Cortex in proportion to 500 grams altogether, reflux extraction at 95 ℃ twice, first time add 60% ethanol of 5 times of raw material medicine, add 60% ethanol of 3 times of raw material medicine for the second time , each time for 1.5 hours, the combined extracts were subjected to high-speed centrifugation at 5000r / min for 25min to remove the precipitate to obtain the ethanol extract. Weigh 1707.5 grams of concentrated powder of Bupleurum, Scutellaria, Anemarrhena, Artemisia annua, Betel nut, Rhubarb, and buffalo horn in proportion, add water to decoct twice, add 8 times the amount of water for the first time, and add raw materials for the second time 7 times the amount of water, each time for 2 hours, combined the decoction, concentrated to 3000 g, and removed the precipitate by high-speed centrifugation at 500...

Embodiment 2

[0014] Adopt the method of embodiment one to obtain mixed solution A. The mixed solution A was recovered ethanol at a vacuum degree of 0.08MPa and a temperature of 50°C and concentrated to a certain amount, and the precipitate was removed by high-speed centrifugation at 5000r / min for 10 minutes to obtain the mixed solution B. The mixed liquid B is cross-filtered at 0.06 MPa through a cellulose acetate membrane with a pore size of 0.22 μm-nitrocellulose microfiltration membrane, and the permeated liquid is collected as the clarified liquid of traditional Chinese medicine.

[0015] The clarity of the syrup prepared by the membrane separation method is about 85%-90% higher than that of the syrup produced by the original process, and the clarity stability of long-term storage is significantly improved.

Embodiment 3

[0017] Adopt the method of embodiment one to obtain mixed solution A. The mixed solution A was recovered ethanol at a vacuum degree of 0.04MPa and a temperature of 45°C, concentrated to a certain amount, and the precipitate was removed by high-speed centrifugation at 5000r / min for 10 minutes to obtain the mixed solution B. The mixed liquid B is cross-filtered at 0.08 MPa through a cellulose acetate membrane with a pore size of 0.45 μm-nitrocellulose microfiltration membrane, and the permeated liquid is collected as the clarified liquid of traditional Chinese medicine.

[0018] The clarity of the syrup prepared by the membrane separation method is about 80%-85% higher than that of the syrup produced by the original process, and the clarity stability of long-term storage is significantly improved.

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Abstract

The invention discloses a method for membrane separation and clarification of traditional Chinese medicine liquid, which belongs to the purification and clarification technology of traditional Chinese medicine liquid. The process of the method comprises: high-speed centrifugation or filtration of the traditional Chinese medicine decoction or extract to remove sediment or part of impurities to obtain a pretreatment liquid A; evaporating the pretreatment liquid A under reduced pressure, concentrating and evaporating or recovering the extractant, Then the precipitate was removed by high-speed centrifugation to obtain the pretreatment solution B; the pretreatment solution B was filtered through the cellulose acetate-nitrocellulose mixed plate microfiltration membrane with a pore size of 0.1-1.0 μm under a certain pressure at room temperature and cross-flow, and the permeate was collected. The liquid is the clarified liquid of traditional Chinese medicine. The invention has the advantages of: the operation is carried out at normal temperature without damaging the active ingredients; the production cycle is shortened; on the basis of ensuring the content of the active ingredients, the clarity of the liquid medicine is increased by 80% to 90%, and the physical and chemical stability is good. The clarity of long-term storage is also significantly improved.

Description

technical field [0001] The invention relates to a method for membrane separation and clarification of traditional Chinese medicine liquid, which belongs to the purification and clarification technology of traditional Chinese medicine liquid. Background technique [0002] The traditional production process of medicinal liquid mainly includes three parts: extraction, impurity removal and monosaccharide addition. The obtained liquid medicine generally has the following problems: ① the appearance of the liquid medicine is relatively turbid, and there are a large amount of suspended matter; Precipitation appears at the bottom; ③The impurity removal rate of the liquid medicine is low, and the dosage of the medicine is relatively large. [0003] Existing methods for producing medicinal liquid mainly include standing method, alcohol extraction method and coarse filtration method, which have long production cycle, high cost and poor effect. Compared with t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8964A61K36/889A61K36/71A61K36/708A61K36/575A61K36/539A61K36/538A61K36/282A61K36/233A61K35/32A61K9/08
Inventor 姜忠义吴洪王姣马小乐王艳强王婷
Owner TIANJIN UNIV
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