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Dispersible tablet of tamoxifen citrate and preparation method thereof

A technology for tamoxifen and dispersible tablets, which is applied in the field of pharmaceutical compositions containing tamoxifen citrate, and can solve problems affecting drug absorption and bioavailability, slow dissolution rate, etc.

Inactive Publication Date: 2005-08-17
马晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the slow dissolution rate of existing preparations, the absorption and bioavailability of the drug are affected

Method used

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Embodiment Construction

[0023] The present invention will be further described below in the form of embodiments, and the implementation details of the present invention will be given, but it is not intended to limit the protection scope of the present invention.

[0024] First, tamoxifen citrate is micronized to a particle size of less than 25 microns, and lactose, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, etc. are all passed through a 100-mesh sieve;

[0025] Weigh 3.5 grams of polyvinylpyrrolidone and 0.7 grams of sodium lauryl sulfate to prepare a mixed aqueous solution for subsequent use.

[0026] Weigh 15.2 grams of micronized tamoxifen citrate, first mix with 3.0 grams of carboxymethyl starch sodium in equal increments, then add 31.5 grams of microcrystalline cellulose and mix thoroughly, then add 91 grams of lactose for grinding Mix, sieve, mix evenly, and add the above-mentioned mixed solution to make a soft material. Use a 30-mesh sieve to wet granulate, d...

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Abstract

The dispersive tamosxifen citrate tablet is prepared through mixing tamosxifen citrate powder of 25 micron below size, microcrystal cellulose, lactose, PVP, sodium dodecyl sulfate and partial sodium carboxymethyl cellulose; pelletizing the mixture into disintegrated pellets of 0.5 mm below size; adding magnesium stearate and the rest sodium carboxymethyl cellulose; and tabletting into the dispersive tablet. The dispersive tamosxifen citrate tablet can disintegrate fast within 2 min and has fast medicine digesting speed and high bioavailability.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition containing tamoxifen citrate, and relates to an improved technology of an oral preparation of tamoxifen citrate. technical background: [0002] The following definitions apply throughout the specification and claims: [0003] Added sodium carboxymethyl starch: refers to the added sodium carboxymethyl starch when preparing disintegrating particles of tamoxifen citrate, which is contained in each disintegrating particle. [0004] Added sodium carboxymethyl starch: refers to the sodium carboxymethyl starch added again when the disintegrated particles of tamoxifen citrate are prepared into tamoxifen citrate tablets. In addition to the disintegrating particles of tamoxifen citrate, it is distributed among the disintegrating particles. [0005] Tamoxifen is a non-steroidal anti-estrogen drug. Since its introduction in the 1970s, it has been used as a standard treatment drug for breast cancer hormone th...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/138A61P35/00
Inventor 马晶
Owner 马晶
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