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Glow release micro pill containing gingko leaf extract and its preparation method

A technology of sustained-release pellets and extracts, applied in the field of sustained-release pellets containing ginkgo biloba extract and its preparation, can solve problems such as difficult quality control and sudden release of sustained-release tablets, and achieve increased safety and fluidity Good, high yield and reproducible results

Inactive Publication Date: 2005-08-10
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, sustained-release tablets are easily affected by operating conditions such as pressure in large-scale production, making it difficult to control the quality, and most of the sustained-release tablets are prone to burst release

Method used

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  • Glow release micro pill containing gingko leaf extract and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1, the preparation of blank pellet

[0041] 1

2

lactose

starch

sucrose

Talc powder

Magnesium stearate

100g

30g

40g

20g

10g

microcrystalline cellulose

starch

hypromellose

silica

Magnesium stearate

80g

60g

20g

20g

20g

[0042] B. Preparation process

[0043] Mix the prescribed amount of lactose or microcrystalline cellulose and starch evenly, add the binder prepared by sucrose or hypromellose, use a granulator or a coating pan to get the mother and spheronize to the required mesh size of 15-30 mesh , add lubricant and glidant while rolling, dry, and sieve out the best 20-30 mesh.

Embodiment 2

[0044] Embodiment 2, the preparation of quick-release pellets

[0045] 1

2

blank pellet

Ginkgo biloba extract

hypromellose

70% ethanol

100g

80g

75g

1.5L

blank pellet

Ginkgo biloba extract

Polyvinylpyrrolidone

80% ethanol

100g

80g

128g

1.5L

[0046] B. Preparation process

[0047] The ginkgo biloba extract, hypromellose or polyvinylpyrrolidone described in the prescription were respectively added to 70% or 80% ethanol, and ultrasonicated for 15 minutes to form a uniform solution. In a fluidized bed or a coating pan, the temperature of the pellets is kept at 30° C., and the solution is evenly sprayed on the outer layer of the blank pellets obtained in Example 1 to prepare immediate-release pellets.

Embodiment 3

[0048] Embodiment 3, the preparation of sustained-release pellets

[0049] 1

2

Drug-containing pellets

Acrylic RS30D

triethyl citrate

Talc powder

100g

70g

14g

17.5g

Drug-containing pellets

ethyl cellulose moisture

bulk

PEG4000

100g

50g

1g

[0050] B. Preparation process

[0051] The instant-release pellets obtained in Example 2 were put into a fluidized bed or a coating pan, and the temperature of the pellets was controlled at 28°C. Add triethyl citrate and talcum powder to acrylic resin RS30D, stir evenly, and spray on the outer layer of immediate-release pellets to make sustained-release pellets.

[0052] Put the quick-release pellets obtained in Example 2 into a fluidized bed or a coating pan, and keep the temperature of the pellets at 38°C. Add PEG4000 into ethyl cellulose aqueous dispersion and stir evenly, spray on the outer layer of quick-release pellets ...

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Abstract

A slow-releasing micropill containing the extract of gingko leaf is prepared through preparing pill core from filler, adhesive and lubricant, preparing mixture of gingko leaf's extract and high-molecular adhesive, coating it on the surface of said pill core to obtain quick-releasing micropill, dissolving the retardent, hole forming agent and plasticizer in solvent, and spraying it on the surface of quick-releasing micropill to obtain the slow-releasing one.

Description

technical field [0001] The invention belongs to the technical field of drug sustained-release preparations, and more specifically relates to a sustained-release pellet containing ginkgo biloba extract and a preparation method thereof. Background technique [0002] Ginkgo biloba L., also known as Gongsun tree, is one of the oldest plants and is known as the living fossil of gymnosperms. According to the records of Compendium of Materia Medica, ginkgo fruit has the functions of astringing the lungs, relieving asthma, stopping enuresis and leucorrhea. Modern pharmacological studies have shown that Ginkgo biloba extract has pharmacological effects such as inhibiting the production of oxygen free radicals, anti-platelet aggregation, improving myocardial tolerance to hypoxia, and improving blood supply in ischemic areas. At present, the common preparations of ginkgo leaf extracts in the domestic market are: Ginkgo biloba extract tablets of Shanghai Xinyi Paluta Pharmaceutical Co....

Claims

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Application Information

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IPC IPC(8): A61K9/16A61P7/02A61P9/10A61P39/06
Inventor 王俊裴元英
Owner FUDAN UNIV
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