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Reduced glutathione soft capsule and manufacturing process thereof

A technology of glutathione and reduced form, applied in the direction of capsule delivery, tripeptide components, anti-toxic agents, etc., can solve the problems of instability and poor compliance of tablets and buccal tablets, achieve convenience in taking, improve stability, overcome The effect of being easily oxidized to oxidized glutathione

Inactive Publication Date: 2005-07-06
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reduced glutathione currently on the market is reduced glutathione for injection, which is not as convenient as oral preparations for clinical use, and patients suffer from certain pains and poor compliance. Currently, reduced glutathione tablets are under development and research and buccal tablets, but because reduced glutathione is easily oxidized to oxidized glutathione in the air, and has strong hygroscopicity, it is less stable when made into tablets and buccal tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Put 1kg of gelatin, 450g of glycerin, 1kg of water, and 2.5g of ethylparaben into a plastic tank and mix evenly, then heat the mixture to about 70-80°C, mix evenly, vacuumize, filter, keep warm and stand for use ; Take 20g glycerin, 180g polyethylene glycol 400, mix evenly, add 7.5g polyethylene glycol 6000, then add 100g reduced glutathione and 0.15g folic acid, fully mix, measure the content, put it in a soft capsule after degassing After being pressed in the manufacturing machine, put it in the setting machine to set the shape, wash and dry, and it is ready.

Embodiment 2

[0039] Mix 1kg of gelatin, 400g of glycerin, 1kg of water, and 2.5g of propyl p-hydroxybenzoate in a plastic tank, then heat the mixture to about 70-80°C, mix evenly, vacuumize, filter, and keep warm. Stand-by; take 20g glycerin, 380g polyethylene glycol 400, mix well, add 18g polyethylene glycol 6000, then add 200g reduced glutathione and 0.12g vitamin C, fully mix, measure the content, degass and put in After pressing in a soft capsule manufacturing machine, put it in a setting machine for setting, wash and dry, and then get it.

Embodiment 3

[0041] Mix 1kg of gelatin, 425g of glycerin, 1kg of water, and 2.5g of ethyl p-hydroxybenzoate in a plastic tank, then heat the mixture to about 70-80°C, mix evenly, vacuumize, filter, and keep warm. Stand-by; take 30g glycerin, 270g polyethylene glycol 600, mix evenly, add 8g polyethylene glycol 4000, then add 100g reduced glutathione and 0.2g folic acid, mix well, measure the content, degas and place in soft After pressing in the capsule making machine, put it in the setting machine for setting, wash and dry, and then get it.

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PUM

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Abstract

The invention discloses a kind of reduced glutathione soft capsule and manufacturing process, wherein the product comprises soup and capsule shell, wherein each capsule of the soup 100-500mg of reduced glutathione, 2.0-3.2% of stabilizer, anti-oxidizing agent and base material, while the capsule shell contains 10 weight parts of gelatin, 4-4.5 parts by weight of glycerine, 10 parts by weight of water and right amount of preservative agent. The capsule has the advantages of good compliance for patients and better constancy.

Description

technical field [0001] The invention relates to a reduced glutathione soft capsule oral preparation and a preparation method thereof, belonging to the technical field of medicines and preparation thereof. technical background [0002] Reduced glutathione is an important component of all cells. It has two main physiological functions, one is anti-oxidation, and the other is integrated detoxification. It can scavenge free radicals and restore other used antioxidants so that they can be recycled; the active group thiol in the reduced glutathione molecule can combine with certain substances to have an integrated detoxification effect. It is mainly used clinically for detoxification, radiation sickness, radiation protection, and liver protection. Reduced glutathione currently on the market is reduced glutathione for injection, which is not as convenient as oral preparations for clinical use, and patients suffer from certain pains and poor compliance. Currently, reduced glutathio...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K38/06A61P1/16A61P17/16A61P39/02A61P39/06
Inventor 孙丽红庄大伟王卓睿张志宏
Owner 北京瑞伊人科技发展有限公司
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