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Oleum fructus bruceae soft capsule and preparation method thereof

A technology of bruce japonica oil and soft capsule, which is applied in the directions of capsule delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as greasy feeling, nausea, etc., achieve accurate content, avoid exudation, and save absorption. Effect

Inactive Publication Date: 2005-07-06
浙江天一堂医药管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the oral dosage form of the patented medicine is only an oil-in-water emulsion made of javanica javanica oil as a raw material and refined soybean lecithin as an emulsifier.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 4000g of Brucea javanica oil, 2500g of gelatin, 875g of glycerin, 10g of antioxidant, and 0.7g of preservative, put gelatin, glycerin, and water in a plastic bucket at a ratio of 1:0.35:0.90, heat to dissolve at 90°C, and add preservative , while stirring for 2 hours, after vacuum degassing, keep warm at 70°C for later use.

[0026] Mix the antioxidant into javanica javanica oil, stir and mix well, let it stand to dissolve, and degas it by ultrasonic for later use.

[0027] Adjust the temperature of the plastic box of the SCM-100 soft capsule machine to 50°C, the temperature of the spray body to 41-43°C, and the thickness of the rubber to 0.7-0.8mm. Pour the medicinal liquid into the medicinal liquid hopper, and press the soft capsule with a mold.

Embodiment 2

[0029] Weigh 2000g of Brucea javanica oil, 400g of gelatin, 140g of glycerin, 5g of antioxidant, and 0.4g of preservative, put gelatin, glycerin, and water in a plastic bucket at a ratio of 1:0.35:0.90, heat and dissolve in a water bath at 95°C, and add antiseptic agent, stirred for 2 hours at the same time, after vacuum degassing, keep warm at 80°C for later use.

[0030] Mix the antioxidant into javanica javanica oil, stir and mix well, let it stand to dissolve, and degas it by ultrasonic for later use.

[0031] Adjust the temperature of the plastic box of the SCM-100 soft capsule machine to 50°C, the temperature of the spray body to 41-43°C, and the thickness of the rubber to 0.7-0.8mm. Pour the medicinal liquid into the medicinal liquid hopper, and press the soft capsule with a mold.

Embodiment 3

[0033] Weigh 3000g of Brucea javanica oil, 1500g of gelatin, 525g of glycerin, 8g of antioxidant, and 0.5g of preservative, put gelatin, glycerin, and water in a plastic bucket at a ratio of 1:0.35:0.90, heat and dissolve in a water bath at 80°C, and add antiseptic agent, stirred for 2 hours at the same time, after vacuuming and degassing, keep warm at 55°C for later use.

[0034] Mix the antioxidant into javanica javanica oil, stir and mix well, let it stand overnight to dissolve it, and degas it by ultrasonic for later use.

[0035] Adjust the temperature of the plastic box of the SCM-100 soft capsule machine to 50°C, the temperature of the spray body to 41-43°C, and the thickness of the rubber to 0.7-0.8mm. Pour the medicinal liquid into the medicinal liquid hopper, and press the soft capsule with a mold.

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Abstract

The invention provides an oleum fructus bruceae soft capsule and preparation method, wherein each capsule comprises oleum fructus bruceae oil 200-500mg and adjuvant containing anti-oxidant, and the capsule shell comprises gelatin 10 parts, glycerin 3-5 parts, water 10 parts and preservative.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine javanica javanica oil soft capsule and a preparation method thereof. Background technique [0002] Brucea javanica is the dry and mature fruit of the plant Bructus javanica of the bitter wood family, which is produced in Guangdong, Hainan, Guangxi, Fujian and other places in my country. In ancient my country, it was widely used among the people to treat amoebic dysentery. Since the 1950s, Brucea javanica has been used externally to treat skin papillomas and common warts. The components of Brucea javanica can be divided into two parts: water-soluble and fat-soluble. The water-soluble components are a series of tetracyclic triterpenoids, and the fat-soluble components are trioleic acid, oleic acid, linoleic acid, and saturated fatty acids, Carbonic acid, dilute acid, etc. Among the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61P35/00
Inventor 王天亮樊雪君王永华
Owner 浙江天一堂医药管理有限公司
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