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Gynostemme pentaphylium soft capsule and its preparing process

A technology of Gynostemma pentaphyllum and soft capsule, which is applied in capsule delivery, medical preparations containing active ingredients, digestive system, etc. It can solve problems such as difficulty in making oral liquid preparations, long disintegration time of tablets, and reduction of the expected curative effect. Achieve the effects of retaining medicinal value, easy long-term storage, and reducing production costs

Inactive Publication Date: 2005-07-06
仵博
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the long disintegration time of the tablet in the body, the bioavailability is low, and the curative effect should be reduced.
Gypenosides have a bitter taste and are not easy to be made into oral liquid preparations. However, the production of tablets still has problems such as complex process, cumbersome procedures, long production cycle, and high production cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] Now describe the present invention in detail in conjunction with embodiment:

[0007] Present embodiment is to be made by the raw material of following percentage by weight:

[0008] Capsule shell: Gelatin 40.77%, Glycerin 14.26%, Macrogol-400 4.08%, Methylparaben 0.12%, Purified Water 40.77%

[0009] Encapsulation solution: Gypenosides 20%, Macrogol-400 70%, Propylene Glycol 10%

[0010] Preparation Process:

[0011] 1. Crush Gypenosides until the particle size is above 120 mesh and set aside;

[0012] 2. Mix polyethylene glycol-400 and propylene glycol for later use, and put the raw material of Gypenosides in a sandwich stainless steel water bath, add the mixed solution and stir to heat to 60-70°C. After the raw materials of Gypenosides are dissolved, filter the filtrate. After degassing by pressure, it becomes capsule liquid, ready for use;

[0013] 3. Put the gelatin in a sandwich stainless steel water bath with stirring and decompression, add purified water, he...

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PUM

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Abstract

The invention discloses a gynostemme pentaphylium soft capsule and its preparing process, wherein the capsule includes capsule shell and capsule liquid, wherein the capsule shell comprises gelatin, glycerin, methyl hydroxybenzoate and purified water, wherein the percentages by weight of the compositions is 1:0.35:0.1:0.003:1, while the capsule liquid comprises gynostemma pentaphylla triterpenes, polyethylene glycol -400 and propylene glycol by the weight percent of 2:7:1. The medicinal granules are obtained from allocated capsule shell and capsule liquid in the soft capsule making machine.

Description

technical field [0001] The invention relates to a gypenoside soft capsule and a preparation process thereof, belonging to the capsule preparation technology. Background technique [0002] Clinical studies have proved that Gynostemma pentaphyllum has obvious strengthening effects, anti-fatigue, prolonging cell life, lowering blood lipid levels, and treating various cancers, and has certain preventive effects on cancer, ulcers, migraines and other symptoms. It is widely used in hypertension, hyperlipidemia, gastric ulcer and other diseases, and has achieved certain curative effect: Gypenosides Tablets have significant curative effect in reducing serum cholesterol, triglyceride and low-density lipoprotein cholesterol, and increasing high-density lipoprotein cholesterol , the total effective rate is 94.8%. However, due to the long disintegration time of the tablet in the body, the bioavailability is low, and the curative effect should be reduced. Gypenosides have a bitter tast...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/704A61P1/04A61P3/06A61P9/12
Inventor 仵博
Owner 仵博
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