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Medicinal resin biological adhering slow-releasing liquid prepn. contg. aciclovir, and its prepn. method

A liquid preparation and bioadhesion technology, applied in the field of medicine, to achieve the effects of feasible process, promotion of absorption and easy production

Inactive Publication Date: 2005-05-25
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above domestic and foreign patents and literature have not yet seen the report of the relevant acyclovir drug resin bioadhesive sustained-release liquid preparation

Method used

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  • Medicinal resin biological adhering slow-releasing liquid prepn. contg. aciclovir, and its prepn. method
  • Medicinal resin biological adhering slow-releasing liquid prepn. contg. aciclovir, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Acyclovir: 600mg;

[0035] Amberlite IRP69: 500mg;

[0036] Hypromellose K15M 50mg

[0037] PEG4000: 200mg;

[0038] PEG400: 5mg;

[0039]Diethyl phthalate: 5mg;

[0040] EC (20cps) 40mg;

[0041] PVP (K90) 8mg

[0042] Carbopol (934P) 16mg

Embodiment 2

[0044] Acyclovir: 600mg;

[0045] Amberlite IRP69: 500mg

[0046] Hypromellose K4M 60mg

[0047] PEG4000: 250mg;

[0048] PEG400: 7mg;

[0049] Diethyl phthalate: 6mg;

[0050] Eudragit RS100 40mg;

[0051] Eudragit RL100 30mg;

[0052] PVP (K30) 20mg

[0053] Avicel (RC591) 20mg

Embodiment 3

[0055] Acyclovir: 600mg;

[0056] Amberlite IRP69: 750mg;

[0057] Hypromellose K100M 40mg

[0058] PEG4000: 300mg;

[0059] PEG400: 10mg;

[0060] Dibutyl sebacate: 7mg;

[0061] EC (45cps) 40mg;

[0062] Tragacanth Gum 7.5mg

[0063] Carbopol (934P) 10mg

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Abstract

A slow-release antiviral medicine in the form of liquid is prepared from acyclovir (30-90 wt%) and auxiliary (10-70 wt.%) including the cationic exchange resin and ethylcellulose and / or acrylic resin for slow releasing and the hydroxypropyl cellulose for adhering. Its advantages are high curative effect and low toxic by-effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to an antiviral drug acyclovir drug resin bioadhesive slow-release liquid preparation administered once a day and a preparation method thereof. Background technique: [0002] Acyclovir, also known as acyclovir (ACV for short), is a nucleoside antiviral drug. The chemical name is 9-[2-hydroxyethoxymethyl]guanine. ACV was first developed abroad by the American Baowei (B.W) company and first listed in September 1981. In China, the Hubei Institute of Pharmaceutical Industry first synthesized it in 1979 and entered the pharmaceutical market in 1990. Now, acyclovir freeze-dried powder, tablets, capsules, eye drops, syrups, creams for external use, suppositories and other dosage forms are on the market. [0003] As an antiviral drug, acyclovir has a broad antiviral spectrum. It has the greatest activity against herpes simplex I and type II viruses, followed by varicella zoster virus. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/522A61P31/12
Inventor 潘卫三刘宏飞刘阳
Owner SHENYANG PHARMA UNIVERSITY
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