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Antineoplastic vascular embolic agent and its preparing process

A vascular embolizing agent, anti-tumor technology, applied in the direction of anti-tumor drugs, suppository delivery, pharmaceutical formulations, etc., can solve the problems of no obvious anti-tumor effect, no righting and immune function enhancement, no anti-tumor effect of Bletilla striata, etc. good biocompatibility

Inactive Publication Date: 2005-03-16
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The treatment results show that Bletilla striata has no clear anti-tumor effect, and its colloidal preparation has no obvious anti-tumor effect when used as a vascular embolism agent, and does not have the effect of strengthening the body and improving immune function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 prepares anti-tumor vascular embolism agent (asparagum agent)

[0024] Prepare asparagus extract fine powder according to the described preparation method, get 15 grams of asparagus extract fine powder, add iodine-containing solution earlier---non-ionic contrast agent Dianbile, (Shanghai Bracco Xinyi Pharmaceutical Co., Ltd. Company product) 30ml, each ml contains 300mg of iodine, put it aside for 24 to 48 hours, after the asparagus extract powder is fully swollen, then add Pyrex to 50ml, mix well, sub-package, and sterilize with circulating steam at 100°C After 1 hour, the finished anti-tumor vascular embolism agent is obtained.

Embodiment 2

[0025] Embodiment 2 prepares anti-tumor vascular embolism agent (asparagum agent)

[0026] Prepare asparagus extract fine powder according to the described preparation method, get 75 grams of asparagus extract fine powder, add iodine-containing solution earlier---non-ionic contrast agent Dianbile (Shanghai Bracco Xinyi Pharmaceutical Co., Ltd. product) 60ml, each ml contains 300mg iodine, place for 24 to 48 hours, after the asparagus extract fine powder is fully swollen, then add Pyramid to 100ml, mix well, sub-package, 100°C circulation steam sterilization 1 Hours, the finished anti-tumor vascular embolism agent is obtained.

Embodiment 3

[0027] Embodiment 3 Anti-tumor vascular embolism agent (asparagus) embolization experiment on rat hepatic artery

[0028] Injecting the asparagus gum preparation of the present invention into the rat hepatic artery can cause blockage of the rat hepatic artery to normal rats and cause local infarction of part of the liver tissue, and it can be seen that the asparagus gum preparation accumulates at the tumor site in rats with primary liver cancer. Pathologically, it shows multiple infarcts in the liver cancer, indicating that the asparagus gum of the present invention is a good peripheral vascular embolism agent.

[0029] The experimental method is as follows:

[0030] 1. Normal rats: select about 250 grams of normal Wistar rats, perform laparotomy for hepatic artery puncture, inject 0.2 ml of this asparagus gum preparation, the concentration is 50 grams of asparagus extract fine powder per 100 ml, under X-ray It can be seen that the asparagine preparation is distributed throug...

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PUM

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Abstract

The invention discloses an antineoplastic vascular embolic agent and its preparing process which consists of using asparagus root for extraction to obtain fine extract powder, charging iodine containing solution. The preparing method provided by the invention can effectively preserve the active constituents in the medicinal materials and simplify preparing traditional Chinese medicinal preparations.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to an anti-tumor vascular embolism agent, in particular to a traditional Chinese medicine colloid preparation with anti-tumor drug effect and a preparation method thereof. Background technique [0002] Transarterial chemoembolization has been recognized as the most effective conservative therapy for malignant tumors, especially for primary or metastatic liver cancer. However, the adverse effects of chemoembolic agents have become a key factor affecting the quality of life and survival of patients after treatment. According to clinical epidemiological research reports, statistical analysis of various syndromes of intervention patients found that intervention can damage yin, help heat, and generate dampness. Yin deficiency and other syndromes in the intervention group increased significantly, and it was believed that "yin deficiency may be unique to liver cancer, and we must...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/12A61K9/02A61P35/00
Inventor 张闽光耿坚刘力黄学菁刘瑾邢东玮唐岚
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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