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Medicinal composition containing danshensu, total ara-saponin and camphol and its preparation and use

A technology of Panax notoginseng saponins and Danshensu, which is applied in the medicine combination group of Panax notoginseng saponins and borneol, and contains Danshensu, which can solve the problem of difficult dissolution

Active Publication Date: 2005-03-02
广东天之骄生命科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention adopts the methods of water extraction, alkali hydrolysis and ethyl acetate extraction to extract the active ingredient mainly Danshensu from Danshen; adopts the method of water extraction and alcohol precipitation, and the method of passing through a macroporous adsorption resin column to extract and purify from Radix Notoginseng The active ingredients of Panax notoginseng saponins; the borneol in the prescription is clathrated by using hydroxypropyl β-cyclodextrin (HP-β-CD), which solves the problem that it is difficult to dissolve in the aqueous solution of injection, and improves the preparation Quality and Clinical Efficacy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] (1) The prescription of raw material medicine is: Danshen 500g, borneol 10g, notoginseng 160g;

[0087] (2) Take Danshen medicinal herb pieces and crush them, add 10 times the amount of water to decoct 4 times, 3 hours each time, combine the extracts and filter, let the filtrate cool, high-speed centrifugation (15000rpm), and use ultrafiltration with a molecular weight cut-off of 5000 for the centrifugation Membrane ultrafiltration, adding Na(OH) to the filtrate 2 Adjust the pH value of the lye to 9, boil for 3 hours, let it cool, refrigerate (4°C) for 24 hours and filter, adjust the pH value of the filtrate to 1 with hydrochloric acid, extract 9 times with 3 times ethyl acetate, and combine the ethyl acetate solution , concentrated and dried under reduced pressure to obtain a Danshen extract with Danshensu as the main component (the weight percentage of Danshensu was 28.57% after testing).

[0088] (3) Take Panax notoginseng herb decoction pieces and crush them, decoc...

Embodiment 2

[0092] (1) The prescription of the raw material medicine is: Salvia miltiorrhiza 400g, borneol 6g, notoginseng 120g;

[0093] (2) Take Danshen medicinal herb pieces and crush them, add 6 times the amount of water to decoct twice, each time for 1 hour, combine the extracts and filter, let the filtrate cool, high-speed centrifugation (15000rpm), and use an ultrafiltration filter with a molecular weight cut-off of 5000 for the centrifugate Membrane ultrafiltration, filtrate added NaCO 3 Adjust the pH value of the lye to 11, boil for 0.5 hours, let it cool, refrigerate (4°C) for 24 hours, and filter it. The filtrate is adjusted to a pH value of 3 with sulfuric acid, extracted 3 times with 0.5 times ethyl acetate, and the ethyl acetate solution is combined. Concentrate and dry under reduced pressure to obtain a Danshen extract with Danshensu as the main component (the weight percentage of Danshensu is 26.75% after testing).

[0094] (3) Take Panax notoginseng herbal decoction piec...

Embodiment 3

[0098] (1) The prescription of the raw material medicine is: Salvia miltiorrhiza 450g, borneol 8g, notoginseng 141g;

[0099] (2) Take Danshen medicinal herb pieces and crush them, add 8 times the amount of water to decoct 3 times, 2 hours each time, combine the extracts and filter, let the filtrate cool, high-speed centrifugation (15000rpm), and use an ultrafiltration filter with a molecular weight cut-off of 5000 for the centrifugate Membrane ultrafiltration, adding Ca(OH) to the filtrate 2 Adjust the pH value of the lye to 10, boil for 2 hours, let it cool, refrigerate (4°C) for 24 hours and filter, adjust the pH value of the filtrate to 2 with phosphoric acid, extract 7 times with 1.5 times ethyl acetate, and combine the ethyl acetate solution , concentrated and dried under reduced pressure to obtain a Danshen extract with Danshensu as the main component (the weight percentage of Danshensu was 29.73% after testing).

[0100] (3) Take Panax notoginseng herb decoction piece...

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Abstract

The medicinal composition of the present invention is compound freeze dried red sage powder for injection comprising red sage extract with danshensu as main component, notoginseng extract with arasaponin as main component, hydroxypropyl beta-cyclodextrin clathrate of borneol and medicinal supplementary material. The preparation process includes extracting red sage component via water extraction, ultrafiltering, alkali hydrolysis and ethyl acetate extraction; extracting notoginseng component via water extraction, alcohol precipitation and macro resin adsorption; clathrating borneol to raise its water solubility; and other steps. The present invention is used in preventing and treating cardiac and cerebral vascular diseases and has obvious curative effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a medicine combination group containing danshensu, panax notoginseng saponins and borneol, as well as its preparation and application. This pharmaceutical composition is also called compound salvia miltiorrhiza freeze-dried powder injection. Background technique [0002] Coronary heart disease and angina pectoris are clinically common and frequently-occurring diseases. In recent years, with the improvement of people's living standards, the age of onset of coronary heart disease has advanced. Coupled with the aging of the population structure, the incidence rate is increasing year by year. The development of drugs for the treatment of cardiovascular and cerebrovascular diseases has gradually become a research hotspot. More and more clinical reports have shown that traditional Chinese medicine has a good application prospect in the treatme...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/704A61P9/10
Inventor 张正生
Owner 广东天之骄生命科技有限公司
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