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Plant extracts for preventing eye from fatigue and their preparation and preparing method

A plant extract, asthenopia technology, applied in the directions of medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve the problem of no clear treatment purpose, and achieve the enhancement of body immunity, simple equipment and low production cost Effect

Inactive Publication Date: 2005-02-23
天津市壹杯红生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patents such as CN00121388.1 disclose a grape seed extract OPCs strong anti-oxidation composite capsule and its manufacturing method, which is a compound health product that can delay aging and regulate the immune function of the body; CN02159540.2 uses grape seed extract as raw material Patents for capsules used for anti-aging, anti-cancer, anti-oxidation, improving cardiovascular and cerebrovascular, etc., without specific therapeutic purposes
It can be seen that there is no patented invention that uses modern extraction technology and quality control methods to make grape waste residue into modern (standard extract) pharmaceutical preparations for preventing and treating visual fatigue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: A kind of RAT preparation method of grape waste residue

[0026] The raw material is grape waste residue, which is extracted twice with 50% ethanol under reflux, each time the dosage is 7 to 5 times the weight of the original medicinal material, and the extraction time is 2 to 1 hour. The extracts are combined, filtered, ethanol is recovered, and concentrated to obtain the extract. Dilute the extract by 120 times with water, and put it on a resin column for adsorption. The ratio of raw material weight to resin volume is 1:3, and the ratio of resin column diameter to column height is 1:15. Wash with pH=6 water and 50% ethanol solution. The flow rate is 1 column volume / hour.

[0027] Collect the ethanol eluate, add decolorant according to 5% volume of the eluent, heat to reflux for 3 hours, filter, concentrate under reduced pressure, and dry in vacuum to obtain the product. The content of OPCs in grape waste residue can reach more than 50% by this method. ...

Embodiment 2

[0028] Embodiment 2: A kind of RAT preparation method of grape waste residue

[0029] The raw material is grape waste residue, which is extracted 3 times with 60% ethanol under reflux. paste. Dilute the extract by 150 times with water, and put it on a resin column for adsorption. The ratio of raw material weight to resin volume is 1:5, and the ratio of resin column diameter to column height is 1:20. Wash with pH=8 water and 60% ethanol solution. off at a flow rate of 2 column volumes / hour. The eluent was concentrated under reduced pressure and dried in vacuo to obtain the obtained product. The content of OPCs in grape waste residue can reach more than 50% by this method.

Embodiment 3

[0030] Embodiment 3: the preparation of the grape waste residue extract (standard extract) soft capsule and drop pill that OPCs is greater than 50%

[0031] Take the capsule material made of grape waste residue extract with more than 50% OPCs and gelatin, adopt the pressing method to make pills, shape, dry, select and wash the pills, and make soft capsules; adopt the dropping method to make pills, after shaping, drying, selecting Pills, washed pills, made drop pills. The OPCs content of the prepared soft capsule and drop pill preparation should be more than 50%.

[0032] Toxicology Clinical Trials

[0033] The efficacy and safety of the standard extracts and compositions of the present invention will be further proved through clinical and toxicological tests.

[0034] Experimental drug: the preparation made directly from the standard extract of the present invention without adding auxiliary materials is called OPCs in the test.

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PUM

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Abstract

A Chinese medicine for preventing and treating visual fatigue is prepared from the seed, peel and stem of grape through pulverizing, extracting in water and then in alcohol, and purifying by macroreticular resin.

Description

Technical field: [0001] The invention relates to a plant extract, a preparation and a preparation method, in particular to a grape waste residue extract, a preparation and a preparation method for preventing visual fatigue. technical background: [0002] Eye fatigue is caused by the voluntary efforts of the optic apparatus to obtain clear vision with insufficient adjustment, such as blurred vision, eye swelling, eye pain, headache, shoulder and back pain, and mental fatigue. With the rapid development of the information age and the acceleration of the pace of life, especially video display terminals (VDTs) such as computers, TVs, game consoles, and monitors have gradually integrated into people's work, study, and family life. Common diseases seriously affect people's life. It is not an independent disease, but a group of fatigue syndromes caused by various reasons, also known as eye fatigue syndrome. At present, physical therapy for treatment includes prism correction, sur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P27/02
Inventor 孙宝山赵余庆
Owner 天津市壹杯红生物技术有限公司
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