Heparin compound, and its preparing method and use
A technology of compound and heparin, which is applied in the field of heparin compound and its preparation, can solve the problems of low solubility of lithium salt, affecting test quality, unsuitability, etc.
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Embodiment 1
[0012] According to zinc sulfate (ZnSO 4 ) and ammonia (NH 4 The molar ratio (i.e. the molar ratio) of OH) is 1:8, put zinc sulfate into ammonia water, stir at 40°C for 1.5 hours, filter to obtain the precipitate, dry and pulverize to obtain powdery hydroxide Zinc (Zn(OH) 2 ) solid, spare.
[0013] Prepare heparin sodium, zinc hydroxide (Zn(OH) 2 ), potassium hydroxide (KOH), take 1 mole of heparin sodium, 4 moles of zinc hydroxide and 2 moles of potassium hydroxide; dissolve the heparin sodium in water, and then pass the heparin sodium aqueous solution through the A long tubular device for exchanging resin to convert heparin sodium into heparin to obtain an aqueous heparin solution; then add the above-mentioned zinc hydroxide and potassium hydroxide to the aqueous heparin solution, stir for 2 hours at normal temperature and pressure, and then put the liquid at 55°C Drying at a low temperature yields 1 mole of the desired heparin compound (ie heparin zinc potassium) as a s...
Embodiment 2
[0019] According to zinc sulfate (ZnSO 4 ) and ammonia (NH 4 The molar ratio (i.e. molar ratio) of OH) is 1:7, put zinc sulfate into ammonia water, stir for 2 hours at 45°C, filter to obtain the precipitate, dry and pulverize to obtain powdery hydroxide Zinc (Zn(OH) 2 ) solid, spare.
[0020] Prepare heparin sodium, zinc hydroxide (Zn(OH) 2 ), potassium hydroxide (KOH), take 1 mole of heparin sodium, 5 moles of zinc hydroxide and 1 mole of potassium hydroxide; dissolve the heparin sodium in water, and pass the aqueous solution of heparin sodium through the A long tubular device for exchanging resin to convert heparin sodium into heparin to obtain an aqueous heparin solution; then add the above-mentioned zinc hydroxide and potassium hydroxide to the aqueous heparin solution, stir at normal temperature and pressure for 1.5 hours, and then put the liquid at 56°C Drying at a low temperature yields 1 mole of the desired heparin compound (ie heparin zinc potassium) as a solid. ...
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