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Medicinal composition for treating anemopyretic cold and its preparation method

A wind-heat type, drug technology, applied in the direction of drug combination, anti-infective drugs, pharmaceutical formulations, etc., can solve problems such as unsatisfactory curative effect

Active Publication Date: 2005-02-16
扬州中惠制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many kinds of Chinese patent medicines for the treatment of common cold existing on the market, but the curative effect is all unsatisfactory, and there is an urgent need for a kind of high-efficiency Chinese medicine preparation for wind-heat type cold in clinic

Method used

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  • Medicinal composition for treating anemopyretic cold and its preparation method
  • Medicinal composition for treating anemopyretic cold and its preparation method
  • Medicinal composition for treating anemopyretic cold and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: pharmacological experimental research

[0045] 1. In vitro antibacterial experiment

[0046] Drugs and Materials

[0047] Jinqing oral liquid: batch number: 961226, specification: 20ml / bottle (including crude drug 1.0g / ml), the pH value before the experiment was adjusted to 7.2±0.2.

[0048] Shuanghuanglian oral liquid: produced by Harbin Pharmaceutical No. 3 Factory, China, batch number: 970124125, the pH value before the experiment was adjusted to 7.2±0.2.

[0049] strain

[0050] 3.1 Staphylococcus aureus E120;

[0051] 3.2 Staphylococcus epidermidis (Staphylococcus albus) E121;

[0052] 3.3 Streptococcus pneumoniae M301;

[0053] 3.4 Beta-hemolytic Streptococcus M403;

[0054] 3.5 Streptococcus pneumoniae (clinical isolate);

[0055] 3.6 Beta-hemolytic streptococci (clinical isolates)

[0056] All the strains were purchased from the Department of Microbiology, Henan Medical University, and the clinical isolates were identified.

[0057] In the...

experiment example 2

[0171] Experimental Example 2: Clinical Efficacy Research

[0172] Objects and Methods

[0173] case selection

[0174] Formulated in accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines for Cold Treatment". For the selection of experimental cases, a combination of hospitalized cases and identified cases was used, among which no less than one-third of the hospitalized cases were used, and variable factors were strictly controlled for the identified cases.

[0175] Combining syndrome differentiation and disease differentiation, the dual diagnosis of Chinese and Western medicine is adopted.

[0176] The diagnostic criteria for wind-heat-cold in adults are drawn up in accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines for Cold Treatment".

[0177] 1. TCM diagnostic criteria:

[0178] (1) Symptoms such as chills, fever, nasal congestion, runny nose, sneezing, coughing, headache, and general malaise.

[0179...

specific Embodiment approach

[0307] The preparation method of the medicine for treating wind-heat type cold of the present invention is described in further detail below in conjunction with specific examples:

[0308] Example 1:

[0309] 1. 20kg of Bupleurum bupleuri and 17kg of notopterygium are crushed into 3-4mm particles, add 16 times of water together with 30kg of honeysuckle, 20kg of Artemisia annua, and 20kg of forsythia, soak for 1.5 hours, distill for 7 hours, collect aromatic water, carry out secondary distillation, aromatic water The amount collected is 1.5 times the amount of medicinal materials, and Tween-80 is added to make the concentration 0.06%, and it is set aside, and the mother liquor and aqueous solution are separately used for standby;

[0310] 2. Add 14 times of water to 18 kg of Moutan cortex, add 5% sodium chloride, soak in warm for 2.5 hours, distill, collect 9 times of distillate, refrigerate overnight, filter to obtain crystals, and set aside; the distilled aqueous solution is ...

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Abstract

The invention discloses a medicine compound for curing wind-heat type cold and its manufacturing method. The medicine compound is made up of honeysuckle, root of large-flowered skullcap, bupleurum root, southernwood, weeping forsythia, giant knotweed, gardenia, root-bark of peony, notopterygium, liquorice according a certain proportion. The manufacturing method is: pupleurum root, notopterygium, honeysuckle and southernwood are distilled with water; the mother liquid and volatile oil are for backup. The root-bark of peony is distilled with water and acquires the cortex moutan phenol crystal; or packages the crystal for backup. All the medicine dredges are combined, and they are stewed with water, the filtered liquid and the distilled water liquid are combined for backup. The root of large-flowered skullcap, giant knotweed, gardenia and liquorice are stewed in water, the filtered liquid is combined with above mentioned medicine liquid, and they are condensied to thick extractive plaster. Finally, the excepient and flavor correcting agent into the medicine, thus the product can be acquired. The medicine has functions of surface penetrating and heat clearing and detoxification.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating wind-heat type cold and a preparation method thereof. The pharmaceutical composition is a kind of Chinese herbal medicine as a raw material, which is appropriately extracted and mixed with an appropriate amount of medicinal flavoring agent or / and pharmaceutical excipients. The prepared compound preparation Background technique [0002] Wind-heat type cold is a common exogenous disease caused by wind-heat evil attacking the human body, with fever as the main symptom, accompanied by nasal congestion, runny nose, sore throat, dry mouth and thirst, head and body pain and other clinical manifestations. Patients often seek emergency medical attention because of high fever. The so-called acute upper respiratory tract infection in western medicine belongs to this scope. Etiology has confirmed that more than 90% are viral infections, which have certain infectivity, high incidence rate, and are...

Claims

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Application Information

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IPC IPC(8): A61P31/00
Inventor 张红
Owner 扬州中惠制药有限公司
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