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Method for detecting early diagnosis of uterus cancer related to HPV16/18 early protein antibody utilizing polypeptide

An HPV16 and early protein technology, which is applied in the field of early diagnosis of uterine cancer related to the detection of HPV16/18 early protein antibodies by peptides, can solve the problems of lack of early diagnosis technology of cervical cancer, and achieve the effect of easy operation.

Inactive Publication Date: 2005-01-26
BEIJING SHUWEIKANG BIOCHEM TECH
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  • Summary
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  • Application Information

AI Technical Summary

Problems solved by technology

However, the early diagnosis technology for cervical cancer is still lacking

Method used

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Embodiment Construction

[0018] The early (E) protein is coupled with the patient's serum or secretion fluid and the small molecule polypeptide in the 96-well microplate after the polypeptide binding reaction, and the enzyme-linked reaction color development (ELISA) to achieve the result of detecting positive patients. The tested serum is only Need (5-10ul), vaginal secretions (10ul) to complete the reaction of the whole process, the whole process only takes about 2-3 hours to complete, and the test strip only needs 10-20 minutes.

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Abstract

This invention discloses a method for early stage diagnosis of uterine neck cancer related to HPV16, 18 early and late stage protein antibody by using specific polypeptide. It utilizes that the expression of MHC major histocompatibility complex I, II antigen and the existence of tumour and the defection before cancerization of uterine cervix are intimately involved, especially the HLA which is associated with the cancerization of uterine cervix esoderma cell, (CIN) immersed cancer, and cervical carcinoma is human leukocyte antigen molecule, and all immunity decomposing in the body with a series of complex cell-conducting changes into little polypeptide molecule combining break and is connected with MHC. The HLA-DR antigen in the high uterine cervix defecting time CIN III markedly increases expression and regulate and control. The cellular immunity medium (CMI) is immune to HVS, E2, E4, E6 and E7 polypeptide and is connected with antibody of HPV16 early protein by screening polypeptide sequence which is associated with height and antibody.

Description

technical field [0001] The invention relates to a method for early diagnosis of cervical cancer by using specific polypeptide in medicine, and belongs to the technical field of international patent classification C07K14 / 00 "peptides with more than 20 amino acids". Background technique [0002] Cervical cancer is one of the most common tumors in women. According to statistics, there are 450,000 cervical cancer patients in the world, and about 1 million people in the United States are infected with HPV every year S of new cases and 13,000 women were diagnosed with cervical cancer and 50,000 with carcinoma in situ of the cervix. According to the latest report this year, about 10 million women worldwide suffer from high-grade cancer-causing abnormalities, and 30 million women suffer from low-grade cancer-causing abnormalities. In addition, about 300 million women infected with HPVS are normal cells, but have the potential to become cancerous. Studies have shown that HPV infect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/547G01N33/574
Inventor 卞穗敏
Owner BEIJING SHUWEIKANG BIOCHEM TECH
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