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Preparing process of medicinal composition for treating acute and chronic bronchitis

A technology for chronic bronchitis and composition, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of uncontrollable preparation quality, inconvenient storage and taking, backward technology and dosage form, etc. Control quality, improve particle properties, and satisfy clinical absorption effect

Inactive Publication Date: 2004-12-29
SICHUAN RENDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Its technology and dosage form are backward, it is not convenient to store and take, the bioavailability is not high, and the quality of the preparation cannot be controlled.

Method used

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  • Preparing process of medicinal composition for treating acute and chronic bronchitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 The preparation of pharmaceutical composition capsule of the present invention

[0027] Ephedra 283g, licorice 226g, bitter almond (stir-fried) 142g, French pinellia 113g, scutellaria baicalensis (steamed with wine) 85g, Araceae (manufactured) 85g, perilla seed (stir-fried) 85g, mint 85g, bellflower 85g, Fritillaria 85g, 85g mulberry skin, 85g tangerine peel, 57g aster;

[0028] The above thirteen flavors, tangerine peel and peppermint add 8 times the amount of water to distill and extract the volatile oil for 6 hours, collect the volatile oil, filter, and the filtrate and medicinal residues are used for later use. Ephedra, Pinellia, and Fritillaria were respectively extracted with 8 times the amount of 60% ethanol (adjusted to PH=5 with 20% hydrochloric acid) for 3 times, each time for 1 hour, filtered (300 mesh), combined filtrates, and recovered under reduced pressure The relative density of ethanol Zhiqing ointment is 1.06~1.08 (60°C), for later use; t...

Embodiment 2

[0030] Embodiment 2 Preparation of pharmaceutical composition tablet of the present invention

[0031] Ephedra 466g, licorice 80-372g, fried bitter almonds 50-234g, French pinellia 40-186g, wine steamed scutellaria baicalensis 30-140g, made Aria 30-140g, fried perilla seeds 30-140g, mint 30-140g, bellflower 30g ~140g, Fritillaria 30~140g, Morus alba 30~140g, Tangerine peel 30~140g, Aster 20~94g;

[0032] The above thirteen flavors, tangerine peel and peppermint add 8 times the amount of water to distill and extract the volatile oil for 6 hours, collect the volatile oil, filter, and the filtrate and medicinal residues are used for later use. Ephedra, Pinellia, and Fritillaria were respectively extracted with 8 times the amount of 60% ethanol (adjusted to PH=5 with 20% hydrochloric acid) for 3 times, each time for 1 hour, filtered (300 mesh), combined filtrates, and recovered under reduced pressure The relative density of ethanol Zhiqing ointment is 1.06~1.08 (60°C), for later ...

Embodiment 3

[0033] Embodiment 3 The content control of the index component of the pharmaceutical composition of the present invention

[0034] Accurately weigh about 1.5 g of the drug content of the present invention prepared in Example 1, put it in a 25 ml measuring bottle, add an appropriate amount of methanol, ultrasonicate for 60 minutes, let it cool, add methanol to dilute to the mark, shake well, filter, discard the initial For the filtrate, accurately measure 10ml of the filtrate, put it on a water bath and evaporate to dryness, add methanol to the residue to dissolve it, and quantitatively transfer it to a 5ml volumetric flask, dilute to the mark, shake well, and use it as the test solution. Take another ephedrine hydrochloride reference substance, add methanol to make a solution containing 1.5mg per 1ml, as the reference substance solution. Test according to thin-layer chromatography (Appendix IVB, Chinese Pharmacopoeia, 2000 edition one), draw reference substance solution 1 μ l ...

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Abstract

The medicine composition for treating acute and chronic bronchitis is prepared with Chinese ephedra, licorice, almond, pinellia tuber, skullcap root and other eight kinds of Chinese medicinal materials, and through certain preparation process. The medicine composition has high effective component content, small dosage, and ephedrine selected as quality index component to make the medicine composition safe, effective, stable and controllable. The present invention provides one new clinically selected material.

Description

technical field [0001] The invention relates to a preparation method of a medicinal composition for treating acute and chronic bronchitis, in particular to a preparation method of a medicinal composition using traditional Chinese medicine as a raw material, belonging to the field of traditional Chinese medicine. Background technique [0002] Acute trachea and bronchitis are common clinical diseases and frequently-occurring diseases, which are caused by factors such as viral or bacterial infection, physical and chemical stimulation, and allergic reactions. As long as they are actively treated, most patients can recover in a short period of time. Unhealed or recurrent outbreaks can develop into chronic bronchitis. Chronic bronchitis is a chronic non-specific inflammatory syndrome, which is generally caused by internal factors such as local defense of the respiratory tract, decreased immune function, autonomic nerve dysfunction, allergies, and genetics, plus external factors su...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61P11/00
Inventor 陈仁德张廷模
Owner SICHUAN RENDE PHARMA
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