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Composite Chinese medicine gelling agent for treating osteo arthropathy and preparing method thereof

A technology of compound gel and osteoarthritis, which is applied in the direction of bone diseases, medical formulas, medical preparations containing active ingredients, etc., can solve the problems of achieving effective blood drug concentration, affecting drug efficacy, and difficult to control dosage, etc., to achieve Avoid gastrointestinal irritation, reduce the frequency of administration, and reduce the effects of toxic and side effects

Inactive Publication Date: 2004-12-29
SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral preparations of traditional Chinese medicine often contain highly toxic drugs such as Aconitum Aconiti, Araceae, and Nuxyche, and the dose is difficult to control. From the perspective of biopharmaceuticals, it is difficult to achieve effective blood drug concentration in the lesion, which affects the efficacy of the drug.
[0004] The theory of "external treatment of internal diseases" in traditional Chinese medicine has a long history and has accumulated a large number of good and proven prescriptions. However, traditional Chinese medicine for external treatment generally has disadvantages such as backward dosage forms, large doses, and inconvenient use. Traditional Chinese medicine preparations for external use have become an important topic in the modernization of traditional Chinese medicine

Method used

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  • Composite Chinese medicine gelling agent for treating osteo arthropathy and preparing method thereof

Examples

Experimental program
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Effect test

example 1

[0011] Example 1: Preparation of gel

[0012] Formula and ratio:

[0013] Raw Aconitum Extract 1.5g Datura Flower Extract 1g

[0014] Camphor 0.1g Musk 0.04g

[0015] Carbopol 940 1g EDTA-Na 2 0.05g

[0016] Propylene Glycol 10ml Glycerin 5ml

[0017] Triethanolamine 1.5g distilled water to 100g

[0018] The preparation method is: fully swell Carbopol 940 with 40 times of distilled water, and add Aconitum aconitum extract, Dajinhua extract, camphor, musk, glycerin, EDTA-Na 2 , propylene glycol and triethanolamine, add distilled water to 100g, stir evenly to form a gel. Each gram of gel contains 2.6mg of scopolamine.

example 2

[0019] Example 2: Preparation of gel

[0020] Formula and ratio:

[0021] Raw Aconitum Extract 1.5g Datura Flower Extract 1g

[0022] Camphor 0.1g Musk 0.04g

[0023] Hypromellose 1.5g Azone 5ml

[0024] Propylene glycol 15ml Ethylparaben 0.1g

[0025] Glycerin 15g distilled water to 100g

[0026] The preparation method is as follows: add hypromellose to 50 times of distilled water to fully swell, add raw Aconitum aconitum extract, Dajinhua extract, camphor, musk, glycerin, azone, propylene glycol, ethyl hydroxybenzoate respectively according to the above ratio Ester and ethylparaben, add distilled water to 100g, stir evenly, and form a gel. Each gram of gel contains 2.6mg of scopolamine.

example 3

[0027] Example 3: Preparation of gel

[0028] Formula and ratio:

[0029] Raw Aconitum Extract 1.5g Datura Flower Extract 1g

[0030] Camphor 0.1g Musk 0.04g

[0031] Polyvinylpyrrolidone 2g Benzalkonium Bromide 0.05g

[0032] Glycerin 12ml distilled water to 100g

[0033] The preparation method is as follows: add polyvinylpyrrolidone to 50 times of distilled water to fully swell, add Aconitum aconitifolia extract, Dajinhua extract, camphor, musk, glycerin, benzalkonium bromide respectively according to the above ratio, add distilled water to 100g, Stir evenly to form a gel. Each gram of gel contains 2.6mg of scopolamine.

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Abstract

The present invention belongs to the field of Chinese medicine technology, and is especially one kind of compounding Chinese gel preparation for treating osteoarthropathy and its preparation process. The Chinese gel preparation consists of raw aconite root extractive, datura flower extractive, camphor, musk, polymer as matrix, solvent, humectant, preservative and other supplementary material. Compared with available technology, the Chinese gel preparation for transdermal administration of the present invention has no irritation to gastrointestinal tract, lowered body blood medicine concentration, reduced toxic side effect, prolonged acting period, raised patient compliance to the medicine, easy use and low cost.

Description

[technical field] [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine compound gel for treating osteoarthritis and a preparation method thereof. [technical background] [0002] Osteoarthropathy (hyperosteogeny, intervertebral disc herniation, etc.) is a clinically common and frequently occurring intractable disease, which belongs to the category of arthralgia in traditional Chinese medicine. Special epidemiological surveys show that the incidence of this disease among middle-aged and elderly people in my country is as high as 70%, among which the incidence of cervical spine, lumbar spine and knee joint is the highest, and the three together account for more than 90% of bone and joint diseases. In an aging society, this problem is even more prominent. [0003] In the existing methods for the treatment of osteoarthropathy, Western medicine often adopts oral non-steroidal antipyretic analgesics or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P19/02
Inventor 顾清
Owner SHANGHAI YOUSEEN NEW MEDICINE EXPLOITION
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