Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound

A technology of biodegradable materials and process methods, applied in the fields of medical biodegradable materials, ring-opening polymerization of cyclic ester monomers, and synthesis of polyester polymers, can solve hidden dangers of safety, cytotoxicity, and removal of tin-containing catalysts And other issues

Inactive Publication Date: 2004-12-22
NANKAI UNIV
View PDF0 Cites 24 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a relatively serious problem in the biodegradation synthesis of polyester materials at home and abroad: divalent tin compounds, which are used for polymerization reactions and are recognized as the best commercial catalysts for catalytic efficiency (such as: polylactic acid synthesized by melting polycondensation method) , the commercial catalyst stannous chloride of polyglycolic acid and tin protochloride-p-toluenesulfonic acid, the commercial catalyst stannous octoate) of ring-opening polymerization synthetic polylactic acid, polyglycolic acid has cytotoxicity, because after polymerization reaction cannot Tin-containing catalysts are completely removed from the synthesized polymers, which brings such materials as human medicinal and medical materials, especially long-term application materials (carriers for long-term medication, long-term implantable medical materials, etc.) Unsafe hidden danger

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound
  • Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound
  • Technological method of catalytic synthesizing medical biodegradable material with biomass organic guanidine compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In the reaction kettle, 144 grams of lactide were charged, and 119 mg of creatine was added according to monomer: catalyst=1000: 1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (150° C.) for a certain period of time for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The water phase was filtered off, and finally the precipitate was placed in a vacuum drying oven and dried under vacuum at 50° C. for 24 hours to obtain a white powdery solid with a yield of 97%. The polymer molecular weight is 1.0~2.0×10 4 , PDI≤1.40.

Embodiment 2

[0020] 144 grams of lactide were charged into the reactor, and 113 milligrams of creatinine was added according to monomer:catalyst=1000:1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (130° C.) for a certain period of time for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The water phase was filtered off, and finally the precipitate was placed in a vacuum drying oven and dried in vacuum at 50° C. for 24 hours to obtain a white powdery solid with a yield of 98.5%. The polymer molecular weight is 1.0~2.0×10 4 , PDI≤1.30.

Embodiment 3

[0022] In the reactor, 144 grams of lactide were charged, and 105 mg of guanidinoacetic acid was added according to monomer: catalyst=1000: 1 (molar ratio). Vacuumize the reactor, then replace it with nitrogen and repeat the operation three times, close the reactor under vacuum, heat the reactor slowly, and react at a constant temperature (150° C.) for a certain period of time for 72 hours. After stopping the reaction, the reactor was cooled to room temperature, and then acetone was added to dissolve the polymer in the reactor. Deionized water was then added to precipitate the polymer. The aqueous phase was filtered off, and finally the precipitate was placed in a vacuum drying oven and dried in vacuum at 50° C. for 24 hours to obtain a white powdery solid with a yield of 96.5%. The polymer molecular weight is 1.0~2.0×10 4 , PDI≤1.40.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A process for catalytically synthesizing the medical biodegradable material features that the non-toxic non-metal biologic organic guanidine compound (bio-GD), such as creatine, creatinine, and guanidinoacetic acid, is used as catalyst for the open-loop polymerizing reaction of cycloester monomers (L-lactide, glycolide, etc). Its advantage is no environmental pollution.

Description

technical field [0001] The invention relates to a medical biodegradable material, in particular to a new process for synthesizing polyester polymers, using biomass organic guanidine compound bio-GD (creatine, creatinine, guanidinoacetic acid) as a catalyst for cyclic esterification The invention relates to ring-opening polymerization of (lactide, lactone) monomers, belonging to the technical field of polymer chemistry. Background technique [0002] In recent years, with the rapid development of medicine and biological tissue engineering science in the world, the demand for medical biodegradable materials has grown rapidly at home and abroad. In artificially synthesized medical biodegradable materials, aliphatic polyester [such as: poly L-lactic acid P (L-LA), poly D, L-lactic acid P (D, L-LA), polyglycolic acid PGA, polyhexamethylene Lactone PCL and its copolymers, etc.] are the most valued. Due to the excellent biocompatibility and biosafety of this kind of material, it h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G63/08C08G63/82
Inventor 李弘王晨宏赵晓娜
Owner NANKAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com