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Capillary array electrophoretic ratating laser scanning co-focusing fluorescent inspecting instrument

A capillary array and laser scanning technology, used in fluorescence/phosphorescence, instruments, measuring devices, etc., can solve the problem of slow data collection by scanning, and achieve the effect of less sample consumption, high accuracy, and accurate data collection.

Inactive Publication Date: 2004-12-08
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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Problems solved by technology

These two methods have their own advantages and disadvantages. Imaging detection requires high laser intensity and the same laser intensity irradiated on each capillary, while scanning requires mechanical movement of laser or array capillary, and high mechanical technology requirements for controlling back-and-forth translation. High accuracy is required, and the speed of scanning data acquisition is slow

Method used

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  • Capillary array electrophoretic ratating laser scanning co-focusing fluorescent inspecting instrument
  • Capillary array electrophoretic ratating laser scanning co-focusing fluorescent inspecting instrument
  • Capillary array electrophoretic ratating laser scanning co-focusing fluorescent inspecting instrument

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Embodiment

[0022] The whole device mainly includes laser 1, high voltage power supply 2, capillary 3, first buffer pool 4, second buffer pool 5, first electrode 6, second electrode 7, mirror 8, second mirror 24, dichroic mirror 9 , lens 10, second lens 26, optical filter 11, diaphragm 12, photomultiplier tube 13, regulated power supply 14, high-speed biaxial DC motor 15, rotary encoder 16, support rod 17, motor support seat 18, hollow Cylinder 19, the garden cylinder ring 20 that the symmetrical circumference is distributed with aperture, decoding circuit 21, data acquisition card 22, computer 23, cut-off sheet 25 form.

[0023] Put the cylinder ring 20 on the hollow cylinder 19, then fix the cylinder 19 on the support seat 18, fix the capillary 3 through the small hole on the cylinder ring 20, and connect the two ends of the capillary 3 to the first buffer pool 4, respectively. The second buffer pool 5, the biaxial DC motor 15 is fixed in the cylinder 19, the lower shaft of the biaxial ...

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Abstract

An electrophoresis apparatus which is composed of laser, high speed DC motor, rotary coder, high voltage power supply, capillary, buffer solution, reflector and detector is arranged as the follows, capillary is laid out in round shape of symmetric array, high speed DC motor is applied to quicken data collection speed and rotary coder is applied to confirm position of each capillary accurately, rotary reflector is set on central axle of round column on capillary, its reflection face and central axle are presented as of 45 degree angle and laser is focused on capillary, fluorescent signal excited on capillary is transmitted to detector along with light path.

Description

technical field [0001] The invention relates to a capillary array electrophoresis instrument, in particular to a capillary array electrophoresis rotary laser scanning confocal fluorescence detector. Background technique [0002] With the development of combinatorial chemistry, hundreds of drugs are synthesized in one day, and the characterization and analysis of these drugs require high-throughput instruments and methods, requiring the development of high-throughput drugs and bioanalysis techniques. The application of capillary electrophoresis in analytical chemistry is becoming more and more extensive. The detection of inorganic ions and organic organisms has been reported and has become an important analytical tool. Capillary electrophoresis has the characteristics of fast analysis speed, low sample consumption and high separation efficiency. The size is suitable for multi-channel analysis, so capillary array electrophoresis technology has gradually developed. [0003] At...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N27/447
Inventor 汪俊孙光明白吉玲王利
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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