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Freeze-dried 'Shengmai' powder for injection and its preparing process

A technology for freeze-dried powder injections and injections, which can be used in freeze-dried transportation, medical preparations containing active ingredients, anti-inflammatory agents, etc. It can solve the impact of clinical drug safety and effectiveness, poor stability, and unfavorable storage and other problems, to achieve the effect of improved stability, not easy to oxidize, and easy to store

Inactive Publication Date: 2004-11-10
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the existing Shengmai powder injection——Shengmai Injection has a good curative effect on cardiovascular system diseases in clinical practice, the production process uses the three herbs to be extracted separately and then mixed, the red ginseng is extracted by ethanol reflux method, and Schisandra is extracted by water. After steam distillation, the medicinal dregs are further extracted by the hydroalcoholic method. The hydroalcoholic method is used for the extraction of Ophiopogon japonicus, which is not only cumbersome, but also violates the original purpose of the traditional Chinese medicine compound.
In addition, due to the limitation of the aqueous dosage form, the stability is not good, which is not conducive to storage, and has a certain impact on the safety and effectiveness of clinical medication.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment one: specification 100 bottles,

[0077] a. Weigh the raw materials according to the ratio: 100g ginseng, 250g Ophiopogon japonicus, 200g Schisandra chinensis.

[0078] b. Extract Schisandra chinensis with 10 times the amount of 65% ethanol under reflux for 2 times, each time for 60 minutes, recover the ethanol until there is no alcohol smell, add ethanol under stirring to make the alcohol content reach 70%, let stand after fully stirring, filter, Concentrate under reduced pressure, recover ethanol until there is no alcohol smell, and obtain extract A.

[0079] c. Decoct the schisandra medicinal residues extracted with ethanol, ginseng and Radix Ophiopogon japonicus with 10 times the amount of water mentioned above, twice, each time for 90 minutes. After the combined water extracts are concentrated, add ethanol to make the alcohol content reach 70%, carry out alcohol precipitation twice, filter, combine the filtrate, recover the ethanol until it has no alcoh...

Embodiment 2

[0082] Embodiment two: specification 1000 bottles,

[0083] a. Weigh the raw materials according to the ratio: 1000g of ginseng, 3000g of Ophiopogon japonicus, 1500g of schisandra.

[0084] b. Extract Schisandra chinensis with 8 times the amount of 80% ethanol under reflux for 2 times, each time for 120 minutes, recover the ethanol until there is no alcohol smell, add ethanol under stirring to make the alcohol content reach 80%, let stand after fully stirring, filter, Concentrate under reduced pressure, recover ethanol until there is no alcohol smell, and obtain extract A.

[0085] c. Decoct the schisandra medicinal residues extracted with ethanol, ginseng and Radix Ophiopogon japonicus with 12 times the amount of water mentioned above, twice, each time for 90 minutes. After the combined water extracts are concentrated, add ethanol to make the alcohol content reach 60%, ethanol precipitation, filter, the filtrate, add ethanol again, make the alcohol content reach 80%, after s...

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Abstract

The invention discloses a freeze dried injection for restoring pulse beat which is prepared from the extracted significant portions of gen-seng, ophiopogon root and schisandra fruit. The invention also discloses the process for its preparation, which features in the complete extraction of the active ingredient of the used medicinal materials and preserves the polysaccharide component. The freeze powder and injection preparation has very good protecting action for myocardial ischemia.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and relates to a pharmaceutical preparation for treating cardiovascular diseases and a preparation method thereof, in particular to a Shengmai freeze-dried powder for injection and a preparation method thereof. Background technique [0002] Shengmai Injection is derived from "Internal and Inner Injury Debates". Shengmai San is an ancient prescription composed of ginseng, Ophiopogon japonicus and Schisandra chinensis. Too many patients with clinical dialectics of deficiency of both qi and yin. Modern pharmacology has proved that it has the functions of reducing platelet aggregation, enhancing myocardial contractility, improving myocardial hypoxia tolerance, dilating coronary arteries, anti-arrhythmia, anti-virus, anti-inflammation and immune regulation, etc. It is widely used clinically for myocardial infarction, cardiogenic Treatment of shock, coronary heart disease...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61P9/00A61P9/06A61P9/10A61P29/00
Inventor 张晴龙
Owner 张晴龙
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