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Pregnenolone in steroid species and isomeric compound in application of preparing medicaton for treating high blood pressure

A technology of isomers and pregnenolone, which is applied in the preparation of drugs for the treatment of hypertension. In the field of pregnenolone and its isomers, it can solve difficult hypertension, expensive medicines, etc. problem, to achieve the effect of simple preparation process, low toxicity and low price

Inactive Publication Date: 2004-10-27
赵华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the 1990s, my country began to introduce new antihypertensive drug Lusartan from abroad. Its mechanism is to lower blood pressure by antagonizing the stress response caused by angiotensin II. However, due to its high drug price, it is restricted in China. Therefore, the current treatment of hypertension mainly adopts symptomatic therapy, and it is difficult to completely control the occurrence of hypertension fundamentally.
Steroid pregnenolone (Pregnanolone) and its isomers have not been reported in domestic and foreign literature as drugs for controlling hypertension

Method used

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  • Pregnenolone in steroid species and isomeric compound in application of preparing medicaton for treating high blood pressure
  • Pregnenolone in steroid species and isomeric compound in application of preparing medicaton for treating high blood pressure
  • Pregnenolone in steroid species and isomeric compound in application of preparing medicaton for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Anesthetize the hypertensive rat and expose the skull, drill a hole 1mm behind the bregma and 1.5mm next to the midline, insert a cannula vertically, 3.5-4.0mm deep, fix the catheter on the skull, and inject the physiology into the lateral ventricle through the cannula The pH value of the solution of saline or the drug dissolved therein is 7.2, the injection volume is 0.7μl, and the injection is completed at a constant rate of 1-2min. Each rat is injected with the drug once or twice with an interval of at least 2 hours. Injection 9×10 -4 mol.L -1 For PGN, blood pressure decreased from (20.2±2.0) kPa before administration to (16.7±1.3) kPa, and the difference was (-4.7±1.6) kPa (P<0.001).

Embodiment 2

[0035] Use the above method to inject PGN 9×10 into hypertensive rats -7 mol.L -1 , Blood pressure decreased by (1.2±0.1)kPa.

Embodiment 3

[0037] Use the above method to inject PGN 9×10 into hypertensive rats -6 mol.L -1 , Blood pressure decreased by (3.0±0.4)kPa.

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Abstract

An application of the steroid-type pregnanolone and its isomer in preparing the medicine in the form of orally applied medicine, injection, or table for treating hypertension is disclosed. Its advantages are high curative effect and low toxic by-effect.

Description

Technical field: [0001] The present invention relates to the use of pregnenolone (pregnanolone in English) and its isomers, in particular to a steroid pregnenolone (Pregnanolone) and its isomers in the preparation and treatment of high The application in blood pressure medicine belongs to the pharmaceutical field. Background technique: [0002] Psycho-psychological stress hypertension is closely related to the central nervous system. Studies at home and abroad have proved that there are many substances involved in the formation of stress hypertension, including catecholamine hormones, adrenal cortex hormones, angiotensin II, pancreas Glucagon, etc., especially the role of angiotensin II in the pathogenesis of stress hypertension has been paid more attention. At present, the antihypertensive drugs used clinically mainly achieve the effect of lowering blood pressure through symptomatic treatment of diuresis and vasodilation. Abroad, angiotensin II receptor antagonists, as a new typ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/57A61P9/12
Inventor 赵华
Owner 赵华
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