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Block hydrophobic/oleophobic polyether type polyurethane copolymer, its preparation method and application

A technology of polyether polyurethane and copolymer, applied in the field of preparation of biomedical materials, can solve the problems of large reactivity, difficult to control the distribution of fluorocarbon groups, limited hydrophobic effect, etc., and achieves strong hydrophobicity and excellent anticoagulation. Good performance and solubility

Inactive Publication Date: 2004-10-13
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this grafting method is difficult to control the distribution of fluorocarbon groups on the surface, and its reactivity is greatly affected by the matrix.
[0007] Most of the fluorine-containing polyurethanes are synthesized from fluorinated polyether or fluorinated diisocyanate as raw materials. This product contains fluorocarbon groups in the main chain of the molecular structure, which is restricted by the main chain of the molecule and stronger hydrogen bonds. It is difficult to enter the surface, so its hydrophobic effect is limited. More importantly, this polyurethane has poor solubility, so it is rarely reported in the medical field.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1.0 moles of polytetrahydrofuran polyether glycol (PTMG) with a molecular weight of 2000 and 0.2 moles of fluoroalcohol CF with a single-end hydroxyl group (CF 2 ) 7 CH 2 CH 2 OH, preheated at 120°C for 1 hour, added to the reaction kettle under the protection of argon, and cooled to 60°C. Add 2.0 mol of diphenylmethyl diisocyanate (MDI) (prepared as a 10% N,N-dimethylformamide (DMF) solution), and stir at 80° C. for 2 hours. At 20° C., 0.8 moles of butanediamine with a concentration of 0.025 g / ml dimethylformamide solution was added dropwise, reacted for 0.5 hour under stirring, and continued to react for 30 minutes at 90° C. to complete.

[0026] The size of the contact angle is a common means to characterize the hydrophobicity and hydrophilicity of the surface. Generally speaking, a contact angle lower than 90° is a hydrophilic surface, and a contact angle higher than 90° is a hydrophobic surface. The contact angle of ordinary polyurethane surfaces is 105° , whil...

Embodiment 2

[0031] Clean and saturate the reaction kettle equipped with nitrogen protection tube, thermometer and electric stirrer with nitrogen gas, add 1.0 moles of polytetrahydrofuran ether glycol with molecular weight 2000, and fluoroalcohol CF (CF 2 ) 6 CH 2 CH 2 OH 0.05 mole, preheat at 120°C for 1 hour, add 1.05 mole of preheated diphenylmethyl diisocyanate under stirring at 80°C, stir for reaction, add 0.5 mole of chain extender butanediamine, stir rapidly until the reaction is complete, Extrude and cool to shape.

Embodiment 3

[0033] Add 1.0 moles of polytetrahydrofuran polyether glycol with a molecular weight of 2000 and 5 moles of diphenylmethyl diisocyanate into the reaction kettle under the protection of argon, heat at 80°C and stir, and gradually add the solvent dimethyl diisocyanate within 2 hours. Formamide 600ml, add 0.5 moles of butanediol at 30°C, react for 0.5 hours under stirring, add single-terminal hydroxyl fluoroalcohol CF (CF) at 70°C 2 ) 8 CH 2 CH 2 0.5 moles of OH, stirred and reacted under the protection of argon for 30 minutes, added dropwise 0.5 moles of pentaerythritol (made into a dimethylformamide solution with a concentration of 0.05 g / ml) at 50 ° C, and added butanediamine 2.5 molar reaction to completion.

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PUM

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Abstract

The present invention relates to a block hydrophobic and oleophobic polyether type polyurethane copolymer, its preparation method and application in preparation of biological medicinal material. The end group of the described copolymer is fluorocarbon group, and the described copolymer has the following general formula: PU-[O(CH2)m(CF2)nCF3]x, in which PU represents polyether type polyurethane, n value is 3-20, m value is 0-12, x=2-6. Said preparation method includes copolymerization reaction of diisocyanate and polyether glycol and chain extender in the presence of one-ended hydroxyfluoroalcohol, in which the mole ratio of diisocyanate: polyether glycol: chain extender is 1.0:0.2-0.5:0.5-1.0, and the one-ended hydroxyfluoroalcohol content is 1-20% of weight percentage content of the reaction system, and polymerization temp. is 50-120 deg.C.

Description

technical field [0001] The invention relates to block hydrophobic / oleophobic polyether polyurethane copolymer, its preparation method and its application in the preparation of biomedical materials. Background technique [0002] With the rapid development and interpenetration of polymer science, medicine and biology, biomedical polymers have become new functional materials with broad application prospects, and people have invested a lot of energy in the preparation of polymer biomedical materials. Studies have shown that most polymer materials cause different degrees of blood coagulation when they come into contact with blood. Many medical polymers have been prepared, such as organic cinnamon rubber, polyurethane, polymethacrylate, polyvinyl chloride and polyethylene oxide. Alkanes, etc., some cannot meet the requirements due to mechanical properties, and some have limited clinical application due to poor blood adaptability. [0003] Polyurethane materi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04C08G18/48C08G18/72C09D175/08
Inventor 谢琼丹徐坚戴新华王洪声张小莉罗向东唐文红
Owner INST OF CHEM CHINESE ACAD OF SCI
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