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Extract product of Chinese traditional medicine as well as preparation method and application

A technology of extract and traditional Chinese medicine, applied in the field of licorice extract and its preparation, and peony, can solve the problems of low technical content, low content of measurable components, large dosage, etc., and achieves clear effective components, stable and controllable quality, high content

Inactive Publication Date: 2004-08-11
SICHUAN INST OF CHINESE MATERIA MEDICA
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  • Abstract
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AI Technical Summary

Problems solved by technology

Nevertheless, most of the above-mentioned varieties are crude compound preparations of traditional Chinese medicine, the product grade is not high, the technical content is low, the dosage is large, the active ingredients are not clear, the content of measurable ingredients is low, and there is a lack of strict quality standards and a standardized quality control system.

Method used

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  • Extract product of Chinese traditional medicine as well as preparation method and application
  • Extract product of Chinese traditional medicine as well as preparation method and application
  • Extract product of Chinese traditional medicine as well as preparation method and application

Examples

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Effect test

preparation example Construction

[0012] Chinese medicine extract of the present invention -- the preparation of Paeoniae Radix:

[0013] Add 12 times the amount of water to 5000g peony and licorice, decoct and extract 3 times, 1 hour each time, filter, combine the extracts, pass through the macroporous adsorption resin column, wash with an appropriate amount of water, and then elute with 70% ethanol , collect the ethanol eluate, recover the ethanol under reduced pressure, concentrate into an extract, and dry under reduced pressure to obtain 294 g of paeonol, with a yield of 5.9%. Through content determination, the total amount of paeoniflorin, glycyrrhizic acid and total flavonoid glycosides is 52.9%, of which total paeoniflorin is 29.4%, glycyrrhizic acid is 13.7%, and total flavonoid glycosides is 9.8%.

[0014] The method of content determination:

[0015] Total Paeoniflorin was determined according to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2000 Edition).

[0016] ...

Embodiment 1

[0125] Preparation of Chinese herbal extracts:

[0126] Add 1000g of peony and licorice with 10 times the amount of water, decoct and extract 3 times, 1 hour each time, filter, combine the extracts, pass through the macroporous adsorption resin column, wash with an appropriate amount of water, and then elute with 60% ethanol , collect the ethanol eluate, recover the ethanol under reduced pressure, concentrate into an extract, and dry under reduced pressure to obtain 64.2 g of Paeoniae Radix with a yield of 6.42%. After determination, the total amount of total paeoniflorin, glycyrrhizic acid and total flavonoid glycosides is 54.1%, of which total paeoniflorin 28.6%, glycyrrhizic acid 16.1%, and total flavonoid glycosides 9.4%. Add 17.5g of medicinal starch, mix well, pack into capsules of 0.28g / capsule, and the usage and dosage are 2 capsules each time, three times a day.

Embodiment 2

[0128] Add 1000g peony and licorice with 15 times the amount of water, decoct and extract twice, 2 hours each time, filter, combine the extracts, pass through the macroporous adsorption resin column, wash with an appropriate amount of water, and then elute with 75% ethanol , collect the ethanol eluate, recover the ethanol under reduced pressure, concentrate into an extract, and dry under reduced pressure to obtain 61.8 g of paeonol, with a yield of 6.18%. It has been determined that the total amount of total paeoniflorin, glycyrrhizic acid and total flavonoid glycosides is 56.6%, of which, total paeoniflorin 31.2%, glycyrrhizic acid 14.8%, and total flavonoid glycosides 10.6%. Add 21.5g of medicinal starch, mix well, and make a tablet of 0.3g / tablet. The usage and dosage are 2 tablets each time, three times a day.

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Abstract

A Chinese medicine is prepared from peony root and liquorice root through decocting, filtering, collecting the filtrate, adsorbing by macroreticular adsorptive resin, eluting with alcohol, collecting the eluting liquid, recovering alcohol, concentrating and drying. It can be used to treat chronic viral hepatitis B. Its advantage is high curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, especially the extract of peony and licorice, its preparation method and its medical application. technical background [0002] Chronic hepatitis B is a liver lesion caused by long-term infection with hepatitis B virus that cannot be cleared. It is one of the common refractory diseases in the world today. The incidence rate of chronic hepatitis B is very high. According to the report of Center for Disease Control in Atlanta, USA, there are about 270 million HBsAg carriers in the world. At least 600 million people in my country have been infected with hepatitis B virus, and about 120 million people are HBsAg carriers, 1 / 4 of which eventually develop into chronic hepatitis B virus. Chronic viral hepatitis B has a complex transmission route, a long course of disease, easy recurrence and chronicity, and is closely related to liver cirrhosis and liver cancer. It is ver...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/16A61P31/12C07H1/08C07J63/00
Inventor 易进海赵军宁
Owner SICHUAN INST OF CHINESE MATERIA MEDICA
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